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- W2034157127 abstract "We had previously demonstrated that opioid receptors contribute to the induction and expression of behavioral sensitization induced by repeated daily injection with 2.5 mg/kg of methamphetamine for 7 days. Using the same regimen, the present study investigated the alterations in mu-opioid receptor during the induction (on days 2, 5, and 8) and expression (on days 11 and 21) periods of behavioral sensitization. Radioligand binding revealed that the maximal binding of mu-opioid receptor was not changed on days 2 and 5, but down-regulated on day 8. After cessation of drug treatment, the maximal binding of mu-opioid receptor gradually and time-dependently returned to normal level on day 11 and up-regulated on day 21. In contrast, no changes in delta- and kappa-opioid receptors were detectable on any given day examined. The potency of DAMGO for [(35)S]-GTPgammaS coupling was enhanced on days 2, 5, 11, and 21. Moreover, 1 muM of naltrexone or beta-chlornaltrexamine significantly suppressed the basal [(35)S]-GTPgammaS coupling on days 2, 11, and 21. These findings indicate enhanced responsiveness and elevated constitutive activity of mu-opioid receptor. In summary, our data clearly demonstrate that alterations in mu-opioid receptor are involved in and may contribute to the sensitization to locomotor stimulating effect of methamphetamine." @default.
- W2034157127 created "2016-06-24" @default.
- W2034157127 creator A5004481812 @default.
- W2034157127 creator A5042435352 @default.
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- W2034157127 date "2006-07-18" @default.
- W2034157127 modified "2023-10-16" @default.
- W2034157127 title "Methamphetamine-induced behavioral sensitization in mice: alterations in μ-opioid receptor" @default.
- W2034157127 cites W1576180580 @default.
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- W2034157127 cites W1613719983 @default.
- W2034157127 cites W1759725395 @default.
- W2034157127 cites W1821594443 @default.
- W2034157127 cites W1908496136 @default.
- W2034157127 cites W1964103615 @default.
- W2034157127 cites W1964361254 @default.
- W2034157127 cites W1964916807 @default.
- W2034157127 cites W1965835906 @default.
- W2034157127 cites W1966707689 @default.
- W2034157127 cites W1968168940 @default.
- W2034157127 cites W1969780676 @default.
- W2034157127 cites W1971899275 @default.
- W2034157127 cites W1972819146 @default.
- W2034157127 cites W1976032083 @default.
- W2034157127 cites W1976098128 @default.
- W2034157127 cites W1980464927 @default.
- W2034157127 cites W1984237754 @default.
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- W2034157127 cites W2009243814 @default.
- W2034157127 cites W2011645297 @default.
- W2034157127 cites W2016866955 @default.
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- W2034157127 cites W2023392537 @default.
- W2034157127 cites W2029722158 @default.
- W2034157127 cites W2030148193 @default.
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- W2034157127 doi "https://doi.org/10.1007/s11373-006-9102-x" @default.
- W2034157127 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2925105" @default.
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