FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034157397> ?p ?o ?g. }

• W2034157397 endingPage "660" @default.
• W2034157397 startingPage "653" @default.
• W2034157397 abstract "Large interindividual variation in the composition of the intestinal microbiota between unrelated individuals has made it challenging to identify specific aspects of dysbiosis that lead to Crohn's disease (CD). To reduce variations in exposure during establishment of the gut flora and the influence of genotype, we studied the mucosa-associated microbiota of monozygotic twin pairs that were discordant (n = 6) or concordant (n = 4) for CD. DNA was extracted from biopsies collected from 5 locations between the ileum and rectum. Bacterial 16S ribosomal RNA genes were amplified and community composition assessed by terminal-restriction fragment length polymorphism, cloning and sequencing, and quantitative real-time polymerase chain reaction (PCR). The microbial compositions at all biopsy locations for each individual were similar, regardless of disease state, but there were differences between individuals. In particular, individuals with predominantly ileal CD had a dramatically lower abundance (P < 0.001) of Faecalibacterium prausnitzii and increased abundance (P < 0.03) of Escherichia coli compared to healthy co-twins and those with CD localized in the colon. This dysbiosis was significantly correlated to the disease phenotype rather than genotype. The reduced abundance of F. prausnitzii and increased abundance of E. coli are indicative of an ileal CD phenotype, distinct from colonic CD, and the relative abundances of these specific bacterial populations are promising biomarker candidates for differential diagnosis of CD and eventually customized treatment." @default.
• W2034157397 created "2016-06-24" @default.
• W2034157397 creator A5003460678 @default.
• W2034157397 creator A5004588687 @default.
• W2034157397 creator A5006855744 @default.
• W2034157397 creator A5019960092 @default.
• W2034157397 creator A5021804500 @default.
• W2034157397 creator A5049888214 @default.
• W2034157397 creator A5064934970 @default.
• W2034157397 creator A5080482070 @default.
• W2034157397 date "2009-05-01" @default.
• W2034157397 modified "2023-10-14" @default.
• W2034157397 title "Twin studies reveal specific imbalances in the mucosa-associated microbiota of patients with ileal Crohnʼs disease" @default.
• W2034157397 cites W1752248076 @default.
• W2034157397 cites W1966665184 @default.
• W2034157397 cites W1973148749 @default.
• W2034157397 cites W2019720942 @default.
• W2034157397 cites W2022661087 @default.
• W2034157397 cites W2023610631 @default.
• W2034157397 cites W2024372253 @default.
• W2034157397 cites W2027973875 @default.
• W2034157397 cites W2031443391 @default.
• W2034157397 cites W2036677443 @default.
• W2034157397 cites W2042172193 @default.
• W2034157397 cites W2047059509 @default.
• W2034157397 cites W2048058913 @default.
• W2034157397 cites W2056585868 @default.
• W2034157397 cites W2057447694 @default.
• W2034157397 cites W2061791452 @default.
• W2034157397 cites W2066726671 @default.
• W2034157397 cites W2072945208 @default.
• W2034157397 cites W2090646040 @default.
• W2034157397 cites W2091309425 @default.
• W2034157397 cites W2097177097 @default.
• W2034157397 cites W2097875133 @default.
• W2034157397 cites W2105190780 @default.
• W2034157397 cites W2111764011 @default.
• W2034157397 cites W2111858111 @default.
• W2034157397 cites W2119284252 @default.
• W2034157397 cites W2120563211 @default.
• W2034157397 cites W2121187468 @default.
• W2034157397 cites W2122435279 @default.
• W2034157397 cites W2126446070 @default.
• W2034157397 cites W2127449370 @default.
• W2034157397 cites W2144413511 @default.
• W2034157397 cites W2147726663 @default.
• W2034157397 cites W2151088711 @default.
• W2034157397 cites W2151170536 @default.
• W2034157397 cites W2152805980 @default.
• W2034157397 cites W2153732314 @default.
• W2034157397 cites W2153905079 @default.
• W2034157397 cites W2156145269 @default.
• W2034157397 cites W2157584041 @default.
• W2034157397 cites W2158820172 @default.
• W2034157397 cites W2160855953 @default.
• W2034157397 cites W2162748874 @default.
• W2034157397 cites W2165279431 @default.
• W2034157397 cites W2165407078 @default.
• W2034157397 cites W2168296283 @default.
• W2034157397 cites W2169909966 @default.
• W2034157397 cites W2171963518 @default.
• W2034157397 cites W2323949825 @default.
• W2034157397 cites W4248422417 @default.
• W2034157397 doi "https://doi.org/10.1002/ibd.20783" @default.
• W2034157397 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19023901" @default.
• W2034157397 hasPublicationYear "2009" @default.
• W2034157397 type Work @default.
• W2034157397 sameAs 2034157397 @default.
• W2034157397 citedByCount "416" @default.
• W2034157397 countsByYear W20341573972012 @default.
• W2034157397 countsByYear W20341573972013 @default.
• W2034157397 countsByYear W20341573972014 @default.
• W2034157397 countsByYear W20341573972015 @default.
• W2034157397 countsByYear W20341573972016 @default.
• W2034157397 countsByYear W20341573972017 @default.
• W2034157397 countsByYear W20341573972018 @default.
• W2034157397 countsByYear W20341573972019 @default.
• W2034157397 countsByYear W20341573972020 @default.
• W2034157397 countsByYear W20341573972021 @default.
• W2034157397 countsByYear W20341573972022 @default.
• W2034157397 countsByYear W20341573972023 @default.
• W2034157397 crossrefType "journal-article" @default.
• W2034157397 hasAuthorship W2034157397A5003460678 @default.
• W2034157397 hasAuthorship W2034157397A5004588687 @default.
• W2034157397 hasAuthorship W2034157397A5006855744 @default.
• W2034157397 hasAuthorship W2034157397A5019960092 @default.
• W2034157397 hasAuthorship W2034157397A5021804500 @default.
• W2034157397 hasAuthorship W2034157397A5049888214 @default.
• W2034157397 hasAuthorship W2034157397A5064934970 @default.
• W2034157397 hasAuthorship W2034157397A5080482070 @default.
• W2034157397 hasBestOaLocation W20341573971 @default.
• W2034157397 hasConcept C104317684 @default.
• W2034157397 hasConcept C126322002 @default.
• W2034157397 hasConcept C135763542 @default.
• W2034157397 hasConcept C143121216 @default.
• W2034157397 hasConcept C168007829 @default.
• W2034157397 hasConcept C171636592 @default.
• W2034157397 hasConcept C203014093 @default.

• next