FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034157665> ?p ?o ?g. }

• W2034157665 endingPage "131" @default.
• W2034157665 startingPage "125" @default.
• W2034157665 abstract "PURPOSE. To determine whether cultured rabbit corneal epithelial cells (RCEC), grown on permeable supports, provide a suitable in vivo model for characterizing transcellular drug permeation and metabolism. METHODS. Primary rabbit corneal epithelial cells grown in DMEM-F12 were seeded on Transwell-COL inserts coated with fibronectin. The epithelial barrier integrity was evaluated, based on measurements of 14 C-mannitol and 3 H-PEG900, and their transepithelial electrical resistance (TEER). Ultrastructure evaluation was based on scanning electron microscopy and transmission electron microscopy, which were performed 8 days after seeding. Measurements of beta adrenergic antagonist permeability were performed to assess transcellular permeability. RESULTS. Eight days after seeding, the TEER reached a peak of 144 O · cm 2 and the 14 C-mannitol and 3 H-PEG900 permeabilities were 6.8 × 10 -6 and 2.9 × 10 -6 cm/sec, respectively. Ultrastructural analysis revealed a multilayered structure with numerous microplicae and typical cytoplasmic organelles along with desmosomes. The relationship between permeation of ß-blockers and lipophilicity resembled the intact isolated cornea. CONCLUSIONS. This is the first description of cultured RCEC grown on permeable support. Many of its properties mimic those described in the intact corneal epithelium. Even though its electrical tightness is less than that of the intact cornea, the transcellular permeability to lipophilic ß-antagonists is comparable to the isolated preparation. Therefore, this model will facilitate characterization of ocular permeation mechanisms of hydrophobic drugs whose route of permeation is transcellular." @default.
• W2034157665 created "2016-06-24" @default.
• W2034157665 creator A5000855233 @default.
• W2034157665 creator A5001160269 @default.
• W2034157665 creator A5005524486 @default.
• W2034157665 creator A5007049989 @default.
• W2034157665 creator A5042334420 @default.
• W2034157665 creator A5043178645 @default.
• W2034157665 creator A5061634903 @default.
• W2034157665 date "1998-01-01" @default.
• W2034157665 modified "2023-10-16" @default.
• W2034157665 title "Beta adrenergic antagonist permeation across cultured rabbit corneal epithelial cells grown on permeable supports" @default.
• W2034157665 cites W1252895163 @default.
• W2034157665 cites W1606372460 @default.
• W2034157665 cites W1998464185 @default.
• W2034157665 cites W2028273867 @default.
• W2034157665 cites W2036017720 @default.
• W2034157665 cites W2043160795 @default.
• W2034157665 cites W2049891000 @default.
• W2034157665 cites W2054025651 @default.
• W2034157665 cites W2069809327 @default.
• W2034157665 cites W2084081823 @default.
• W2034157665 cites W2087526401 @default.
• W2034157665 cites W2118247610 @default.
• W2034157665 doi "https://doi.org/10.1076/ceyr.17.2.125.5598" @default.
• W2034157665 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9523089" @default.
• W2034157665 hasPublicationYear "1998" @default.
• W2034157665 type Work @default.
• W2034157665 sameAs 2034157665 @default.
• W2034157665 citedByCount "43" @default.
• W2034157665 countsByYear W20341576652012 @default.
• W2034157665 countsByYear W20341576652013 @default.
• W2034157665 countsByYear W20341576652016 @default.
• W2034157665 countsByYear W20341576652017 @default.
• W2034157665 countsByYear W20341576652018 @default.
• W2034157665 countsByYear W20341576652019 @default.
• W2034157665 countsByYear W20341576652022 @default.
• W2034157665 countsByYear W20341576652023 @default.
• W2034157665 crossrefType "journal-article" @default.
• W2034157665 hasAuthorship W2034157665A5000855233 @default.
• W2034157665 hasAuthorship W2034157665A5001160269 @default.
• W2034157665 hasAuthorship W2034157665A5005524486 @default.
• W2034157665 hasAuthorship W2034157665A5007049989 @default.
• W2034157665 hasAuthorship W2034157665A5042334420 @default.
• W2034157665 hasAuthorship W2034157665A5043178645 @default.
• W2034157665 hasAuthorship W2034157665A5061634903 @default.
• W2034157665 hasConcept C105702510 @default.
• W2034157665 hasConcept C120882062 @default.
• W2034157665 hasConcept C12554922 @default.
• W2034157665 hasConcept C142724271 @default.
• W2034157665 hasConcept C169760540 @default.
• W2034157665 hasConcept C176285220 @default.
• W2034157665 hasConcept C185592680 @default.
• W2034157665 hasConcept C2776882836 @default.
• W2034157665 hasConcept C2779257441 @default.
• W2034157665 hasConcept C41625074 @default.
• W2034157665 hasConcept C50670333 @default.
• W2034157665 hasConcept C529295009 @default.
• W2034157665 hasConcept C55493867 @default.
• W2034157665 hasConcept C60903277 @default.
• W2034157665 hasConcept C71924100 @default.
• W2034157665 hasConcept C86803240 @default.
• W2034157665 hasConcept C87555872 @default.
• W2034157665 hasConceptScore W2034157665C105702510 @default.
• W2034157665 hasConceptScore W2034157665C120882062 @default.
• W2034157665 hasConceptScore W2034157665C12554922 @default.
• W2034157665 hasConceptScore W2034157665C142724271 @default.
• W2034157665 hasConceptScore W2034157665C169760540 @default.
• W2034157665 hasConceptScore W2034157665C176285220 @default.
• W2034157665 hasConceptScore W2034157665C185592680 @default.
• W2034157665 hasConceptScore W2034157665C2776882836 @default.
• W2034157665 hasConceptScore W2034157665C2779257441 @default.
• W2034157665 hasConceptScore W2034157665C41625074 @default.
• W2034157665 hasConceptScore W2034157665C50670333 @default.
• W2034157665 hasConceptScore W2034157665C529295009 @default.
• W2034157665 hasConceptScore W2034157665C55493867 @default.
• W2034157665 hasConceptScore W2034157665C60903277 @default.
• W2034157665 hasConceptScore W2034157665C71924100 @default.
• W2034157665 hasConceptScore W2034157665C86803240 @default.
• W2034157665 hasConceptScore W2034157665C87555872 @default.
• W2034157665 hasIssue "2" @default.
• W2034157665 hasLocation W20341576651 @default.
• W2034157665 hasLocation W20341576652 @default.
• W2034157665 hasOpenAccess W2034157665 @default.
• W2034157665 hasPrimaryLocation W20341576651 @default.
• W2034157665 hasRelatedWork W1967920110 @default.
• W2034157665 hasRelatedWork W1998400112 @default.
• W2034157665 hasRelatedWork W2011189203 @default.
• W2034157665 hasRelatedWork W2071488647 @default.
• W2034157665 hasRelatedWork W2082951676 @default.
• W2034157665 hasRelatedWork W2091987168 @default.
• W2034157665 hasRelatedWork W2144856465 @default.
• W2034157665 hasRelatedWork W2186419115 @default.
• W2034157665 hasRelatedWork W2603412106 @default.
• W2034157665 hasRelatedWork W2707015926 @default.
• W2034157665 hasVolume "17" @default.
• W2034157665 isParatext "false" @default.
• W2034157665 isRetracted "false" @default.

• next