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- W2034158129 abstract "Aiming whether intraperitoneal administration of disulfiram (tetraethyl thiuram disulfide, DS) achieves potentially therapeutic drug concentrations in brain tissue, the behaviour of blood-brain barrier (BBB) to 14C-labelled DS in cerebral ischemia with and without simultaneous administration of dimethylsulfoxide (DMSO) was studied in Mongolian gerbils subjected to left common carotid artery (CCA) occlusion. The results indicated that: (a) the permeability of DS through the BBB was significantly enhanced in the ischemic brain during the initial 30 min duration after DS administration; (b) administration of DMSO increased the entry of DS into the ischemic brain five-fold during the first 30 min and it was significantly higher even at the 60 min sampling period; (3) in general, the content of DS in the brain was quickly reduced with time." @default.
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- W2034158129 date "1983-09-01" @default.
- W2034158129 modified "2023-10-16" @default.
- W2034158129 title "Distribution of disulfiram in brain after carotid ligation in gerbils" @default.
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- W2034158129 doi "https://doi.org/10.1016/0028-3908(83)90055-2" @default.
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