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• W2034158668 startingPage "2933" @default.
• W2034158668 abstract "An understanding of the molecular mechanisms of cell fate determination in the nervous system requires the elucidation of transcriptional regulatory programs that ultimately control neuron-type-specific gene expression profiles. We show here that the C. elegans Tailless/TLX-type, orphan nuclear receptor NHR-67 acts at several distinct steps to determine the identity and subsequent left/right (L/R) asymmetric subtype diversification of a class of gustatory neurons, the ASE neurons. nhr-67 controls several broad aspects of sensory neuron development and, in addition, triggers the expression of a sensory neuron-type-specific selector gene, che-1, which encodes a zinc-finger transcription factor. Subsequent to its induction of overall ASE fate, nhr-67 diversifies the fate of the two ASE neurons ASEL and ASER across the L/R axis by promoting ASER and inhibiting ASEL fate. This function is achieved through direct expression activation by nhr-67 of the Nkx6-type homeobox gene cog-1, an inducer of ASER fate, that is inhibited in ASEL through the miRNA lsy-6. Besides controlling bilateral and asymmetric aspects of ASE development, nhr-67 is also required for many other neurons of diverse lineage history and function to appropriately differentiate, illustrating the broad and diverse use of this type of transcription factor in neuronal development." @default.
• W2034158668 created "2016-06-24" @default.
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• W2034158668 date "2009-09-01" @default.
• W2034158668 modified "2023-10-17" @default.
• W2034158668 title "The<i>C. elegans</i>Tailless/TLX transcription factor<i>nhr-67</i>controls neuronal identity and left/right asymmetric fate diversification" @default.
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• W2034158668 doi "https://doi.org/10.1242/dev.040204" @default.
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