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- W2034158679 abstract "The abundance of protein Mitcon: 5, a major component of monocytes and granulocytes as observed by high-resolution two-dimensional electrophoresis, is increased in human fibrolasts treated with interferon or poly I:C. Production of this polypeptide is eliminated in cells treated with dinitrophenol, but not in cells treated with chloramphenicol, indicating that it is a cytoplasmically synthesized mitochondrial protein. Neither chloroquine nor tunicamycin, both of which interfere with proper targeting of lysozomal enzymes, affects Mitcon: 5 production. Actinomycin D prevents induction, indicating that new transcription is required. Cell fractionation studies show that Mitcon: 5 is found in the mitochondria/lysosome fraction, and that it is released from this fraction by treatments designed to liberate matrix enzymes. Mitcon: 5 thus appears to be the first example of a direct effect of interferon treatment on the composition of mitochondria. Furher characterization of this effect may help to explain side-effects of interferon treatment, including fever." @default.
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- W2034158679 date "1985-01-01" @default.
- W2034158679 modified "2023-09-25" @default.
- W2034158679 title "Induction of a mitochondrial matrix protein in human fibroblasts by interferon or poly I:C" @default.
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- W2034158679 doi "https://doi.org/10.1002/elps.1150060606" @default.
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