FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034162108> ?p ?o ?g. }

• W2034162108 endingPage "154" @default.
• W2034162108 startingPage "148" @default.
• W2034162108 abstract "Infusion of angiotensin II (AngII) to hyperlipidemic mice augments atherosclerosis and causes formation of abdominal aortic aneurysms (AAAs). Each of these AngII-induced vascular pathologies exhibit pronounced inflammation. Previous studies demonstrated that coplanar polychlorinated biphenyls (PCBs) promote inflammation in endothelial cells and adipocytes, two cell types implicated in AngII-induced vascular pathologies. The purpose of this study was to test the hypothesis that administration of PCB77 to male apolipoprotein E (ApoE) −/− mice promotes AngII-induced atherosclerosis and AAA formation. Male ApoE−/− mice were administered vehicle or PCB77 (49 mg/kg, i.p.) during week 1 and 4 (2 divided doses/week) of AngII infusion. Body weights and total serum cholesterol concentrations were not influenced by administration of PCB77. Systolic blood pressure was increased in AngII-infused mice administered PCB77 compared to vehicle (156 ± 6 vs 137 ± 5 mmHg, respectively). The percentage of aortic arch covered by atherosclerotic lesions was increased in AngII-infused mice administered PCB77 compared to vehicle (2.0 ± 0.4 vs 0.9 ± 0.1%, respectively). Lumen diameters of abdominal aortas determined by in vivo ultrasound and external diameters of excised suprarenal aortas were increased in AngII-infused mice administered PCB77 compared to vehicle. In addition, AAA incidence increased from 47 to 85% in AngII-infused mice administered PCB77. Adipose tissue in close proximity to AAAs from mice administered PCB77 exhibited increased mRNA abundance of proinflammatory cytokines and elevated expression of components of the renin-angiotensin system (angiotensinogen, angiotensin type 1a receptor (AT1aR)). These results demonstrate that PCB77 augments AngII-induced atherosclerosis and AAA formation." @default.
• W2034162108 created "2016-06-24" @default.
• W2034162108 creator A5004809332 @default.
• W2034162108 creator A5012921008 @default.
• W2034162108 creator A5045422296 @default.
• W2034162108 creator A5056417722 @default.
• W2034162108 creator A5063577486 @default.
• W2034162108 creator A5083874976 @default.
• W2034162108 creator A5087446146 @default.
• W2034162108 date "2011-11-01" @default.
• W2034162108 modified "2023-10-17" @default.
• W2034162108 title "Polychlorinated biphenyl 77 augments angiotensin II-induced atherosclerosis and abdominal aortic aneurysms in male apolipoprotein E deficient mice" @default.
• W2034162108 cites W1841329025 @default.
• W2034162108 cites W1966912126 @default.
• W2034162108 cites W1969754449 @default.
• W2034162108 cites W1973423073 @default.
• W2034162108 cites W1975500952 @default.
• W2034162108 cites W1981474729 @default.
• W2034162108 cites W1982798124 @default.
• W2034162108 cites W1983575289 @default.
• W2034162108 cites W1986444965 @default.
• W2034162108 cites W1988167553 @default.
• W2034162108 cites W1991552371 @default.
• W2034162108 cites W2000898620 @default.
• W2034162108 cites W2012489652 @default.
• W2034162108 cites W2012740979 @default.
• W2034162108 cites W2013697813 @default.
• W2034162108 cites W2015747541 @default.
• W2034162108 cites W2017588114 @default.
• W2034162108 cites W2023068131 @default.
• W2034162108 cites W2031795728 @default.
• W2034162108 cites W2035521809 @default.
• W2034162108 cites W2038658250 @default.
• W2034162108 cites W2046641769 @default.
• W2034162108 cites W2052522179 @default.
• W2034162108 cites W2054178406 @default.
• W2034162108 cites W2056774147 @default.
• W2034162108 cites W2062827640 @default.
• W2034162108 cites W2063688322 @default.
• W2034162108 cites W2065044287 @default.
• W2034162108 cites W2070725804 @default.
• W2034162108 cites W2073836860 @default.
• W2034162108 cites W2080373577 @default.
• W2034162108 cites W2088164105 @default.
• W2034162108 cites W2091399668 @default.
• W2034162108 cites W2103268700 @default.
• W2034162108 cites W2121173772 @default.
• W2034162108 cites W2127235388 @default.
• W2034162108 cites W2127844344 @default.
• W2034162108 cites W2128399447 @default.
• W2034162108 cites W2133192860 @default.
• W2034162108 cites W2140858016 @default.
• W2034162108 cites W2152937815 @default.
• W2034162108 cites W2159351650 @default.
• W2034162108 doi "https://doi.org/10.1016/j.taap.2011.08.028" @default.
• W2034162108 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3220787" @default.
• W2034162108 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21925196" @default.
• W2034162108 hasPublicationYear "2011" @default.
• W2034162108 type Work @default.
• W2034162108 sameAs 2034162108 @default.
• W2034162108 citedByCount "27" @default.
• W2034162108 countsByYear W20341621082012 @default.
• W2034162108 countsByYear W20341621082013 @default.
• W2034162108 countsByYear W20341621082014 @default.
• W2034162108 countsByYear W20341621082015 @default.
• W2034162108 countsByYear W20341621082017 @default.
• W2034162108 countsByYear W20341621082018 @default.
• W2034162108 countsByYear W20341621082019 @default.
• W2034162108 countsByYear W20341621082020 @default.
• W2034162108 countsByYear W20341621082022 @default.
• W2034162108 countsByYear W20341621082023 @default.
• W2034162108 crossrefType "journal-article" @default.
• W2034162108 hasAuthorship W2034162108A5004809332 @default.
• W2034162108 hasAuthorship W2034162108A5012921008 @default.
• W2034162108 hasAuthorship W2034162108A5045422296 @default.
• W2034162108 hasAuthorship W2034162108A5056417722 @default.
• W2034162108 hasAuthorship W2034162108A5063577486 @default.
• W2034162108 hasAuthorship W2034162108A5083874976 @default.
• W2034162108 hasAuthorship W2034162108A5087446146 @default.
• W2034162108 hasBestOaLocation W20341621082 @default.
• W2034162108 hasConcept C126322002 @default.
• W2034162108 hasConcept C134018914 @default.
• W2034162108 hasConcept C2776914184 @default.
• W2034162108 hasConcept C2778163477 @default.
• W2034162108 hasConcept C2779134260 @default.
• W2034162108 hasConcept C2779980429 @default.
• W2034162108 hasConcept C2780520971 @default.
• W2034162108 hasConcept C2908929049 @default.
• W2034162108 hasConcept C57089818 @default.
• W2034162108 hasConcept C62746215 @default.
• W2034162108 hasConcept C71924100 @default.
• W2034162108 hasConcept C84393581 @default.
• W2034162108 hasConceptScore W2034162108C126322002 @default.
• W2034162108 hasConceptScore W2034162108C134018914 @default.
• W2034162108 hasConceptScore W2034162108C2776914184 @default.
• W2034162108 hasConceptScore W2034162108C2778163477 @default.
• W2034162108 hasConceptScore W2034162108C2779134260 @default.
• W2034162108 hasConceptScore W2034162108C2779980429 @default.

• next