FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034163301> ?p ?o ?g. }

• W2034163301 endingPage "S50" @default.
• W2034163301 startingPage "S46" @default.
• W2034163301 abstract "Recombinant hirudin (lepirudin) is a potent direct thrombin inhibitor, which has been approved for the treatment of heparin-induced thrombocytopenia type II (HIT). Because the drug is mainly eliminated by the kidneys, a single loading dose of hirudin may induce therapeutic anticoagulation for up to one week in patients with renal insufficiency. Thus, the use of hirudin in critically ill patients with renal failure could markedly increase their bleeding risk. In this study, hirudin was used in critically ill patients with suspected HIT while on continuous venovenous hemodialysis (CVVHD).Hirudin anticoagulation was performed in seven critically ill patients with suspected HIT. Four patients were initially anuric. Three patients had residual renal function. In all 64 CVVHD treatments (mean duration 12 hr), a polysulfone high-flux hemodialyzer (0.75 m2) with a dialysate flow rate of 1.5 liter/hr and an ultrafiltration rate of up to 200 ml/hr was used. Hirudin was given either as continuous intravenous infusion or as repetitive intravenous boli. Monitoring of anticoagulation was performed by measurements of the systemic activated partial thromboplastin time (aPTT).Hirudin dosage had to be individualized according to the risk of bleeding or clotting. During CVVHD, a continuous intravenous infusion (0.006 to 0.025 mg/kg body wt/hr, N = 2) or repetitive intravenous boli (0.007 to 0.04 mg/kg, N = 5) were given. Two patients required blood transfusions prior to and during hirudin treatment. In five patients without a high bleeding risk, the hirudin dose was adjusted to achieve the target aPTT (1.5 to 2.0 x baseline) in order to prevent thrombotic complications or frequent clotting in the extracorporal circuit. Hirudin dose requirements depended on residual renal function and extracorporal clearance.We conclude from these first clinical data that anticoagulation with hirudin in critically ill patients on continuous hemodialysis can be performed without excessive bleeding risk by combining close clinical and laboratory monitoring. The hirudin dose has to be reduced because of renal failure, and may require adjustment for residual or recovering renal function and extracorporal elimination." @default.
• W2034163301 created "2016-06-24" @default.
• W2034163301 creator A5072052505 @default.
• W2034163301 creator A5072496429 @default.
• W2034163301 creator A5083668462 @default.
• W2034163301 date "1999-11-01" @default.
• W2034163301 modified "2023-09-23" @default.
• W2034163301 title "Recombinant hirudin (lepirudin) as anticoagulant in intensive care patients treated with continuous hemodialysis" @default.
• W2034163301 cites W116242010 @default.
• W2034163301 cites W1968797532 @default.
• W2034163301 cites W2012257575 @default.
• W2034163301 cites W2039135839 @default.
• W2034163301 cites W2059591383 @default.
• W2034163301 cites W2070676143 @default.
• W2034163301 cites W2109289067 @default.
• W2034163301 cites W2408800704 @default.
• W2034163301 cites W2417899551 @default.
• W2034163301 cites W2426068811 @default.
• W2034163301 cites W2810677641 @default.
• W2034163301 doi "https://doi.org/10.1046/j.1523-1755.56.s72.2.x" @default.
• W2034163301 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10560805" @default.
• W2034163301 hasPublicationYear "1999" @default.
• W2034163301 type Work @default.
• W2034163301 sameAs 2034163301 @default.
• W2034163301 citedByCount "66" @default.
• W2034163301 countsByYear W20341633012012 @default.
• W2034163301 countsByYear W20341633012013 @default.
• W2034163301 countsByYear W20341633012015 @default.
• W2034163301 countsByYear W20341633012018 @default.
• W2034163301 countsByYear W20341633012019 @default.
• W2034163301 countsByYear W20341633012020 @default.
• W2034163301 countsByYear W20341633012021 @default.
• W2034163301 crossrefType "journal-article" @default.
• W2034163301 hasAuthorship W2034163301A5072052505 @default.
• W2034163301 hasAuthorship W2034163301A5072496429 @default.
• W2034163301 hasAuthorship W2034163301A5083668462 @default.
• W2034163301 hasBestOaLocation W20341633011 @default.
• W2034163301 hasConcept C126322002 @default.
• W2034163301 hasConcept C141071460 @default.
• W2034163301 hasConcept C2776301958 @default.
• W2034163301 hasConcept C2776710957 @default.
• W2034163301 hasConcept C2777292125 @default.
• W2034163301 hasConcept C2777557582 @default.
• W2034163301 hasConcept C2778063415 @default.
• W2034163301 hasConcept C2778205648 @default.
• W2034163301 hasConcept C2778261982 @default.
• W2034163301 hasConcept C2778271848 @default.
• W2034163301 hasConcept C2778810321 @default.
• W2034163301 hasConcept C2779026020 @default.
• W2034163301 hasConcept C2779161974 @default.
• W2034163301 hasConcept C2780205058 @default.
• W2034163301 hasConcept C42219234 @default.
• W2034163301 hasConcept C57002609 @default.
• W2034163301 hasConcept C71924100 @default.
• W2034163301 hasConcept C89560881 @default.
• W2034163301 hasConceptScore W2034163301C126322002 @default.
• W2034163301 hasConceptScore W2034163301C141071460 @default.
• W2034163301 hasConceptScore W2034163301C2776301958 @default.
• W2034163301 hasConceptScore W2034163301C2776710957 @default.
• W2034163301 hasConceptScore W2034163301C2777292125 @default.
• W2034163301 hasConceptScore W2034163301C2777557582 @default.
• W2034163301 hasConceptScore W2034163301C2778063415 @default.
• W2034163301 hasConceptScore W2034163301C2778205648 @default.
• W2034163301 hasConceptScore W2034163301C2778261982 @default.
• W2034163301 hasConceptScore W2034163301C2778271848 @default.
• W2034163301 hasConceptScore W2034163301C2778810321 @default.
• W2034163301 hasConceptScore W2034163301C2779026020 @default.
• W2034163301 hasConceptScore W2034163301C2779161974 @default.
• W2034163301 hasConceptScore W2034163301C2780205058 @default.
• W2034163301 hasConceptScore W2034163301C42219234 @default.
• W2034163301 hasConceptScore W2034163301C57002609 @default.
• W2034163301 hasConceptScore W2034163301C71924100 @default.
• W2034163301 hasConceptScore W2034163301C89560881 @default.
• W2034163301 hasLocation W20341633011 @default.
• W2034163301 hasLocation W20341633012 @default.
• W2034163301 hasOpenAccess W2034163301 @default.
• W2034163301 hasPrimaryLocation W20341633011 @default.
• W2034163301 hasRelatedWork W1992759115 @default.
• W2034163301 hasRelatedWork W2010502481 @default.
• W2034163301 hasRelatedWork W2048833282 @default.
• W2034163301 hasRelatedWork W2061130726 @default.
• W2034163301 hasRelatedWork W2065797774 @default.
• W2034163301 hasRelatedWork W2115993405 @default.
• W2034163301 hasRelatedWork W2182598200 @default.
• W2034163301 hasRelatedWork W2183433007 @default.
• W2034163301 hasRelatedWork W2304938645 @default.
• W2034163301 hasRelatedWork W2416085403 @default.
• W2034163301 hasVolume "56" @default.
• W2034163301 isParatext "false" @default.
• W2034163301 isRetracted "false" @default.
• W2034163301 magId "2034163301" @default.
• W2034163301 workType "article" @default.