FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034165249> ?p ?o ?g. }

• W2034165249 endingPage "107" @default.
• W2034165249 startingPage "97" @default.
• W2034165249 abstract "Alteration of the outer surface protein (Osp) composition--especially that of OspA and OspC--seems to be important for the adaptation of Borrelia burgdorferi sensu lato to its endothermic hosts (mammals) and poikilothermic vectors (ticks). OspA possibly mediates adherence to tick midgut cells thus enabling the borreliae to survive in the vector, while OspC is associated with borrelial invasion of the tick salivary glands and infection of the mammalian hosts. Here we describe the first successful transformation and complementation of a Borrelia afzelii ospC mutant with the wild-type ospC in trans. To test the influence of OspC on the dissemination behavior in ticks, unfed Ixodes ricinus nymphs were artificially infected by capillary feeding either with B. afzelii wild type, the B. afzelii ospC mutant or the ospC-complemented clone. Tick midguts and salivary glands were investigated after different time intervals for the presence of borreliae and for OspA and OspC by immunfluorescence staining with monoclonal antibodies. While the B. afzelii wild-type strain exhibiting abundant OspC on its surface disseminated to the salivary glands, the OspC-negative mutant was only present in the tick midguts. The ospC-complemented clone which constitutively expresses the wild-type ospC was again able to colonize the salivary glands. This finding demonstrates that OspC is crucial for dissemination of B. afzelii from the tick midgut to the salivary glands, a prerequisite for infection of the warm-blooded host. A summary of the detailed data presented here has already been given in Goettner et al. [2006. OspC of B. afzelii is crucial for dissemination in the vector as shown by transformation and complementation of a European OspC-deficient B. afzelii strain. Int. J. Med. Microbiol. 296S1(Suppl. 40), 122-124]." @default.
• W2034165249 created "2016-06-24" @default.
• W2034165249 creator A5011062072 @default.
• W2034165249 creator A5019895184 @default.
• W2034165249 creator A5033906310 @default.
• W2034165249 creator A5036300284 @default.
• W2034165249 creator A5062474988 @default.
• W2034165249 date "2007-04-01" @default.
• W2034165249 modified "2023-10-15" @default.
• W2034165249 title "Complementation of a Borrelia afzelii OspC mutant highlights the crucial role of OspC for dissemination of Borrelia afzelii in Ixodes ricinus" @default.
• W2034165249 cites W1561668184 @default.
• W2034165249 cites W1572402073 @default.
• W2034165249 cites W1716162574 @default.
• W2034165249 cites W1830124154 @default.
• W2034165249 cites W1836845300 @default.
• W2034165249 cites W1977904572 @default.
• W2034165249 cites W1980173932 @default.
• W2034165249 cites W1988630915 @default.
• W2034165249 cites W1997705188 @default.
• W2034165249 cites W2006517839 @default.
• W2034165249 cites W2014739964 @default.
• W2034165249 cites W2015430118 @default.
• W2034165249 cites W2017094686 @default.
• W2034165249 cites W2019962465 @default.
• W2034165249 cites W2028712666 @default.
• W2034165249 cites W2037947956 @default.
• W2034165249 cites W2047283050 @default.
• W2034165249 cites W2051071992 @default.
• W2034165249 cites W2054835008 @default.
• W2034165249 cites W2059704028 @default.
• W2034165249 cites W2063367477 @default.
• W2034165249 cites W2082345749 @default.
• W2034165249 cites W2087194666 @default.
• W2034165249 cites W2088837736 @default.
• W2034165249 cites W2096917333 @default.
• W2034165249 cites W2104476732 @default.
• W2034165249 cites W2105281406 @default.
• W2034165249 cites W2114228461 @default.
• W2034165249 cites W2117018536 @default.
• W2034165249 cites W2119067612 @default.
• W2034165249 cites W2121386707 @default.
• W2034165249 cites W2131095051 @default.
• W2034165249 cites W2133076235 @default.
• W2034165249 cites W2143138222 @default.
• W2034165249 cites W2143329373 @default.
• W2034165249 cites W2145741346 @default.
• W2034165249 cites W2159988642 @default.
• W2034165249 cites W2166426942 @default.
• W2034165249 cites W2168950809 @default.
• W2034165249 cites W2258615676 @default.
• W2034165249 cites W2312934348 @default.
• W2034165249 cites W4229726285 @default.
• W2034165249 doi "https://doi.org/10.1016/j.ijmm.2006.11.003" @default.
• W2034165249 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17267282" @default.
• W2034165249 hasPublicationYear "2007" @default.
• W2034165249 type Work @default.
• W2034165249 sameAs 2034165249 @default.
• W2034165249 citedByCount "61" @default.
• W2034165249 countsByYear W20341652492012 @default.
• W2034165249 countsByYear W20341652492013 @default.
• W2034165249 countsByYear W20341652492014 @default.
• W2034165249 countsByYear W20341652492015 @default.
• W2034165249 countsByYear W20341652492016 @default.
• W2034165249 countsByYear W20341652492017 @default.
• W2034165249 countsByYear W20341652492018 @default.
• W2034165249 countsByYear W20341652492019 @default.
• W2034165249 countsByYear W20341652492020 @default.
• W2034165249 countsByYear W20341652492022 @default.
• W2034165249 countsByYear W20341652492023 @default.
• W2034165249 crossrefType "journal-article" @default.
• W2034165249 hasAuthorship W2034165249A5011062072 @default.
• W2034165249 hasAuthorship W2034165249A5019895184 @default.
• W2034165249 hasAuthorship W2034165249A5033906310 @default.
• W2034165249 hasAuthorship W2034165249A5036300284 @default.
• W2034165249 hasAuthorship W2034165249A5062474988 @default.
• W2034165249 hasBestOaLocation W20341652492 @default.
• W2034165249 hasConcept C150149183 @default.
• W2034165249 hasConcept C159047783 @default.
• W2034165249 hasConcept C159654299 @default.
• W2034165249 hasConcept C173758957 @default.
• W2034165249 hasConcept C18903297 @default.
• W2034165249 hasConcept C2776127032 @default.
• W2034165249 hasConcept C2778576062 @default.
• W2034165249 hasConcept C2779159148 @default.
• W2034165249 hasConcept C2779620486 @default.
• W2034165249 hasConcept C2780508971 @default.
• W2034165249 hasConcept C2781232936 @default.
• W2034165249 hasConcept C2781453105 @default.
• W2034165249 hasConcept C54355233 @default.
• W2034165249 hasConcept C86803240 @default.
• W2034165249 hasConcept C89423630 @default.
• W2034165249 hasConceptScore W2034165249C150149183 @default.
• W2034165249 hasConceptScore W2034165249C159047783 @default.
• W2034165249 hasConceptScore W2034165249C159654299 @default.
• W2034165249 hasConceptScore W2034165249C173758957 @default.
• W2034165249 hasConceptScore W2034165249C18903297 @default.
• W2034165249 hasConceptScore W2034165249C2776127032 @default.
• W2034165249 hasConceptScore W2034165249C2778576062 @default.

• next