Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034167332> ?p ?o ?g. }
- W2034167332 endingPage "1025" @default.
- W2034167332 startingPage "1014" @default.
- W2034167332 abstract "The effects of the centrally acting anticholinesterase metrifonate (MFT) and its metabolite dichlorvos (2,2-dichlorovinyl dimethyl phosphate; DDVP) on local cerebral glucose utilization (LCGU) have been studied in 3- and 27-month-old rats, using the autoradiographic [ 14 C]deoxyglucose technique. In 3-month-old rats, MFT (80 mg/kg i.p.) increased LCGU significantly in 17 of the 54 regions studied, including insular, cingulate, and temporal cortices, ventral hippocampus, thalamus, lateral habenula, substantia nigra, and superior colliculus. In these regions, the average MFT-induced increase in LCGU was 23% above control. The average hemispheric LCGU increased by 10% (p < 0.01). DDVP (5 mg/kg) increased LCGU in 19 regions (average increase 26%). The average hemispheric LCGU increased by 9% (p < 0.01). Regional distributions of MFT- and DDVP-induced increases in LCGU were similar and overlapped the distribution of the acetylcholinesterase activity. In 27-month-old rats, MFT was active in 18 regions (average increase 25%). The whole-brain mean LCGU increased by 10% (p < 0.01). MFT compensated for the age-related hypometabolism in some brain areas including insular, temporal, and retrosplenial cortices, substantia nigra, and superior colliculus. The effects of MFT on LCGU were preserved in old rats, at variance with other anticholinesterases (tacrine, physostigmine), which are less active in the aged rat brain." @default.
- W2034167332 created "2016-06-24" @default.
- W2034167332 creator A5080331681 @default.
- W2034167332 creator A5086958221 @default.
- W2034167332 creator A5087970127 @default.
- W2034167332 date "1996-09-01" @default.
- W2034167332 modified "2023-09-27" @default.
- W2034167332 title "Effects of Metrifonate, a Cholinesterase Inhibitor, on Local Cerebral Glucose Utilization in Young and Aged Rats" @default.
- W2034167332 cites W1635321914 @default.
- W2034167332 cites W1966088720 @default.
- W2034167332 cites W1970406365 @default.
- W2034167332 cites W1983901172 @default.
- W2034167332 cites W1983916534 @default.
- W2034167332 cites W1984727997 @default.
- W2034167332 cites W1985905543 @default.
- W2034167332 cites W1995346970 @default.
- W2034167332 cites W2010993944 @default.
- W2034167332 cites W2014829480 @default.
- W2034167332 cites W2015413262 @default.
- W2034167332 cites W2016771531 @default.
- W2034167332 cites W2025155885 @default.
- W2034167332 cites W2028594475 @default.
- W2034167332 cites W2034149471 @default.
- W2034167332 cites W2036877965 @default.
- W2034167332 cites W2040346940 @default.
- W2034167332 cites W2041302657 @default.
- W2034167332 cites W2041421158 @default.
- W2034167332 cites W2043868429 @default.
- W2034167332 cites W2045037749 @default.
- W2034167332 cites W2052819815 @default.
- W2034167332 cites W2057213191 @default.
- W2034167332 cites W2057653719 @default.
- W2034167332 cites W2071607346 @default.
- W2034167332 cites W2080168663 @default.
- W2034167332 cites W2090306035 @default.
- W2034167332 cites W2091847351 @default.
- W2034167332 cites W2093374391 @default.
- W2034167332 cites W2117120152 @default.
- W2034167332 cites W2140490317 @default.
- W2034167332 cites W2152250106 @default.
- W2034167332 cites W2365089058 @default.
- W2034167332 cites W324586191 @default.
- W2034167332 cites W47535616 @default.
- W2034167332 cites W95113236 @default.
- W2034167332 doi "https://doi.org/10.1097/00004647-199609000-00027" @default.
- W2034167332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8784247" @default.
- W2034167332 hasPublicationYear "1996" @default.
- W2034167332 type Work @default.
- W2034167332 sameAs 2034167332 @default.
- W2034167332 citedByCount "21" @default.
- W2034167332 countsByYear W20341673322020 @default.
- W2034167332 crossrefType "journal-article" @default.
- W2034167332 hasAuthorship W2034167332A5080331681 @default.
- W2034167332 hasAuthorship W2034167332A5086958221 @default.
- W2034167332 hasAuthorship W2034167332A5087970127 @default.
- W2034167332 hasBestOaLocation W20341673321 @default.
- W2034167332 hasConcept C126322002 @default.
- W2034167332 hasConcept C134018914 @default.
- W2034167332 hasConcept C137183658 @default.
- W2034167332 hasConcept C15744967 @default.
- W2034167332 hasConcept C169760540 @default.
- W2034167332 hasConcept C185592680 @default.
- W2034167332 hasConcept C2775980177 @default.
- W2034167332 hasConcept C2779246727 @default.
- W2034167332 hasConcept C2780723820 @default.
- W2034167332 hasConcept C2780938664 @default.
- W2034167332 hasConcept C2781161787 @default.
- W2034167332 hasConcept C513476851 @default.
- W2034167332 hasConcept C71924100 @default.
- W2034167332 hasConceptScore W2034167332C126322002 @default.
- W2034167332 hasConceptScore W2034167332C134018914 @default.
- W2034167332 hasConceptScore W2034167332C137183658 @default.
- W2034167332 hasConceptScore W2034167332C15744967 @default.
- W2034167332 hasConceptScore W2034167332C169760540 @default.
- W2034167332 hasConceptScore W2034167332C185592680 @default.
- W2034167332 hasConceptScore W2034167332C2775980177 @default.
- W2034167332 hasConceptScore W2034167332C2779246727 @default.
- W2034167332 hasConceptScore W2034167332C2780723820 @default.
- W2034167332 hasConceptScore W2034167332C2780938664 @default.
- W2034167332 hasConceptScore W2034167332C2781161787 @default.
- W2034167332 hasConceptScore W2034167332C513476851 @default.
- W2034167332 hasConceptScore W2034167332C71924100 @default.
- W2034167332 hasIssue "5" @default.
- W2034167332 hasLocation W20341673321 @default.
- W2034167332 hasLocation W20341673322 @default.
- W2034167332 hasOpenAccess W2034167332 @default.
- W2034167332 hasPrimaryLocation W20341673321 @default.
- W2034167332 hasRelatedWork W1979059193 @default.
- W2034167332 hasRelatedWork W1987450218 @default.
- W2034167332 hasRelatedWork W2015327999 @default.
- W2034167332 hasRelatedWork W2034255477 @default.
- W2034167332 hasRelatedWork W2060828139 @default.
- W2034167332 hasRelatedWork W2062579683 @default.
- W2034167332 hasRelatedWork W2089103608 @default.
- W2034167332 hasRelatedWork W2109773872 @default.
- W2034167332 hasRelatedWork W2163744984 @default.
- W2034167332 hasRelatedWork W2171851218 @default.
- W2034167332 hasVolume "16" @default.