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• W2034170844 abstract "During the past few years, three-dimensional crystal structures of many of the important integral membrane proteins responsible for the bioenergetic processes of photosynthesis and respiration have been determined. Moreover, a few crystal structures of protein-protein complexes have become available that characterize the interaction between those membrane proteins and the electron carrier protein cytochrome c. Here, we address the association kinetics for binding of cytochrome c to cytochrome c oxidase (COX) from Paracoccus denitrificans by Brownian dynamics simulations. The effects of ionic strength and protein mutations were studied for two different cytochrome c species: the positively charged, dipolar horse heart cytochrome c and the negatively charged physiological electron transfer partner cytochrome c(552). We studied association toward naked COX and toward membrane-embedded COX where the membrane is represented as an uncharged DPPC bilayer modeled in atomistic detail. For the nonnatural association toward naked COX, the association rates are >100 times larger for horse heart cytochrome c than for cytochrome c(552). Interestingly, the presence of the lipid bilayer leads to a dramatic decrease of the association rate of horse heart cytochrome c, but slightly enhances association of cytochrome c(552), leading to very similar association rates of both proteins to membrane-embedded COX. This finding from computational modeling studies may reflect the optimization of surface patches and of the total net charge on electron transfer pairs in nature." @default.
• W2034170844 created "2016-06-24" @default.
• W2034170844 creator A5027871556 @default.
• W2034170844 creator A5082550931 @default.
• W2034170844 date "2004-07-01" @default.
• W2034170844 modified "2023-10-18" @default.
• W2034170844 title "A Brownian Dynamics Study: The Effect of a Membrane Environment on an Electron Transfer System" @default.
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• W2034170844 doi "https://doi.org/10.1529/biophysj.103.035261" @default.
• W2034170844 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1304388" @default.
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• W2034170844 hasPublicationYear "2004" @default.
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