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- W2034171097 abstract "A rise in drug-resistant bacteria coupled with a decline in the development of new classes of antibiotics has increased the need for new local antibiotic delivery methods. To address this need, we have previously developed layer-by-layer assembled films releasing the potent antibiotic, vancomycin, for use as coatings for on-demand care. In this work, we explore the potential for practical application of these films through an in-depth study of their long term storage stability over a wide range of temperatures, including refrigerator, room and elevated temperature (4, 25 and 37°C, respectively). Our results indicate that the drug-release profiles and minimum inhibitory concentration against Staphylococcus aureus of vancomycin released from films stored at these different conditions are not affected over a period of 1-6 months. Consequently, these films can be used where traditional refrigeration of prepared intravenous vancomycin solutions or immediate reconstitution of lyophilized vancomycin is not possible." @default.
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- W2034171097 date "2012-05-08" @default.
- W2034171097 modified "2023-10-16" @default.
- W2034171097 title "Vancomycin Storage Stability in Multilayer Thin Film Coatings for On-Demand Care" @default.
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- W2034171097 doi "https://doi.org/10.1163/156856211x598256" @default.
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