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- W2034171574 abstract "The submandibular salivary gland of the cat has been perfused in situ at constant volume inflow and in such a way that perfusion periods with kininogen-containing and with kininogenfree perfusates alternated. The gland was stimulated with close arterial injections of nor-adrenaline and the secretory and vascular responses recorded. Doses of noradrenaline which caused vasodilatation or no vascular effects when cat kininogen was present in the perfusate induced brisk vasoconstrictor responses in the same gland when a kininogen-free perfusate was used. The vasoconstrictor responses could be gradually reduced and finally abolished as the gland was reloaded with cat kininogen. Glands which had undergone repeated stimulations with noradrenaline had a markedly lower content of kallikrein than had the contralateral, unstimulated organ. It is concluded that during adrenergic stimulation of the submandibular salivary gland, kallikrein is released into the interstitial space where it induces formation of plasmakinins. The plasma-kinins formed cause vasodilatation, and they probably play an important role in the vasodilator response observed after a period with activation through the sympathetic nerves." @default.
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- W2034171574 date "1972-11-01" @default.
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- W2034171574 title "Plasma-Kinins and Adrenergic Vasodilatation in the Submandibular Salivary Gland of the Cat" @default.
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- W2034171574 doi "https://doi.org/10.1111/j.1748-1716.1972.tb05347.x" @default.
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