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• W2034171971 endingPage "143" @default.
• W2034171971 startingPage "133" @default.
• W2034171971 abstract "We investigated the functional characteristics of the NMDA receptor that modulates hypoxia/hypoglycaemia-induced striatal dopamine release. Dopamine release was detected by fast cyclic voltammetry in rat neostriatal slices. Four variables were measured: Ton — time from initiation of hypoxia/hypoglycaemia to the onset of dopamine release, Tpk — time from onset to maximum, δDA/δt — rate of dopamine release and DAmax — maximum extracellular dopamine concentration. In controls, Ton=164.9±1.7 s, Tpk=20.9±0.9 s, δDA/δt=5.31±0.44 μM/s and DAmax=79.1±2.5 μM (means±S.E.M., n=203). Cis-4-(phosphonomethyl)piperidine-2-carboxylic acid (CGS 19755, 20 μM) lengthened, while N-methyl-d-aspartate (NMDA) (100 μM) shortened Ton. (5R,10S)-(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate (MK 801, 1 and 10 μM) and dextromethorphan (10 and 100 μM) increased Tpk and decreased DAmax. Neither glycine (100 μM), 7-chlorokynurenic acid (50 μM) nor 5-nitro-6,7-dichloro-1,4-dihydroquinoxaline-2,3-dione (ACEA 1021, 100 μM) had any effect although 7-chlorokynurenic acid blocked the effect of NMDA. Increasing [Mg2+] from 1.3 to 3.7 mM, increased Tpk and decreased δDA/δt. Dithiothreitol (1 mM) accelerated Ton while 5,5-dithio-bis-(2-nitrobenzoic acid) (1 mM) delayed Ton. Neither drug affected Tpk, DAmax or δDA/δt. Neither spermidine (100 μM) nor arcaine (100 μM) affected Ton, Tpk or δDA/δt although arcaine decreased DAmax. In conclusion, hypoxia/hypoglycaemia-induced dopamine release was influenced by an NMDA receptor although modulation of the glycine recognition site of the receptor was ineffective, as were agents acting at polyamine modulatory zones. These findings highlight differences between recombinant and native NMDA receptors and suggest caution in extrapolating molecular biology to functional studies." @default.
• W2034171971 created "2016-06-24" @default.
• W2034171971 creator A5012790326 @default.
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• W2034171971 date "1997-12-01" @default.
• W2034171971 modified "2023-10-10" @default.
• W2034171971 title "Characteristics of the NMDA receptor modulating hypoxia/hypoglycaemia-induced rat striatal dopamine release in vitro" @default.
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• W2034171971 doi "https://doi.org/10.1016/s0014-2999(97)01422-2" @default.
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