FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034172298> ?p ?o ?g. }

• W2034172298 endingPage "1438" @default.
• W2034172298 startingPage "1427" @default.
• W2034172298 abstract "The regulatory guidelines (ICHS7B) recommending inhibition of the delayed rectifier K(+) current (I(Kr)), carried by human ether-a-go-go-related gene (hERG) channels in cardiac cells (the hERG test), as a 'first line' test for identifying compounds inducing QT prolongation, have limitations, some of which are outlined here.hERG current was measured in HEK293 cells, stably transfected with hERG channels; action potential duration (APD) and arrhythmogenic effects were measured in isolated Purkinje fibres and perfused hearts from rabbits.576 compounds were screened in the hERG test: 58% were identified as hERG inhibitors, 39% had no effect and 3% were classified as stimulators. Of the hERG inhibitors, 92 were tested in the APD assay: 55.4% of these prolonged APD, 28.3% had no effect and 16.3% shortened APD. Of the 70 compounds without effect on hERG channels, 54.3% did not affect APD, 25.7% prolonged, while 20% significantly shortened APD. Dofetilide (hERG inhibitor; IC(50), 29 nM) prolonged QT and elicited early after-depolarizations and/or torsade de pointes (TdP) in isolated hearts. Mallotoxin and NS1643 (hERG current stimulators at 3 microM), levcromakalim and nicorandil (no effect on hERG current), all significantly shortened APD and QT, and elicited ventricular fibrillation (VF) in isolated hearts.The hERG assay alone did not adequately identify drugs inducing QT prolongation. It is also important to detect drug-induced QT shortening, as this effect is associated with a potential risk for ventricular tachycardia and VF, the latter being invariably fatal, whereas TdP has an approximately 15-25% incidence of death." @default.
• W2034172298 created "2016-06-24" @default.
• W2034172298 creator A5008693707 @default.
• W2034172298 creator A5029079922 @default.
• W2034172298 creator A5033903043 @default.
• W2034172298 creator A5034468485 @default.
• W2034172298 creator A5045394110 @default.
• W2034172298 creator A5054858352 @default.
• W2034172298 creator A5073691282 @default.
• W2034172298 creator A5080586810 @default.
• W2034172298 date "2008-08-01" @default.
• W2034172298 modified "2023-09-25" @default.
• W2034172298 title "Predicting drug-induced changes in QT interval and arrhythmias: QT-shortening drugs point to gaps in the ICHS7B Guidelines" @default.
• W2034172298 cites W1575021701 @default.
• W2034172298 cites W1965633790 @default.
• W2034172298 cites W1967867484 @default.
• W2034172298 cites W1970058620 @default.
• W2034172298 cites W1976335500 @default.
• W2034172298 cites W197638603 @default.
• W2034172298 cites W1977839275 @default.
• W2034172298 cites W1980249371 @default.
• W2034172298 cites W1980463871 @default.
• W2034172298 cites W1983688371 @default.
• W2034172298 cites W1985136179 @default.
• W2034172298 cites W1985572222 @default.
• W2034172298 cites W1992387760 @default.
• W2034172298 cites W1993591031 @default.
• W2034172298 cites W1998949301 @default.
• W2034172298 cites W2006245358 @default.
• W2034172298 cites W2014912931 @default.
• W2034172298 cites W2020721036 @default.
• W2034172298 cites W2030815572 @default.
• W2034172298 cites W2045548568 @default.
• W2034172298 cites W2048975664 @default.
• W2034172298 cites W2050841780 @default.
• W2034172298 cites W2052161755 @default.
• W2034172298 cites W2052230197 @default.
• W2034172298 cites W2054362512 @default.
• W2034172298 cites W2059261131 @default.
• W2034172298 cites W2069187704 @default.
• W2034172298 cites W2074145884 @default.
• W2034172298 cites W2076747420 @default.
• W2034172298 cites W2087376672 @default.
• W2034172298 cites W2089861793 @default.
• W2034172298 cites W2102345870 @default.
• W2034172298 cites W2103223481 @default.
• W2034172298 cites W2104426198 @default.
• W2034172298 cites W2119254321 @default.
• W2034172298 cites W2123048529 @default.
• W2034172298 cites W2147075727 @default.
• W2034172298 cites W2156609021 @default.
• W2034172298 cites W2159011291 @default.
• W2034172298 cites W2161004893 @default.
• W2034172298 cites W2170759882 @default.
• W2034172298 cites W2174038367 @default.
• W2034172298 cites W2572599576 @default.
• W2034172298 doi "https://doi.org/10.1038/bjp.2008.191" @default.
• W2034172298 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2440085" @default.
• W2034172298 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18493243" @default.
• W2034172298 hasPublicationYear "2008" @default.
• W2034172298 type Work @default.
• W2034172298 sameAs 2034172298 @default.
• W2034172298 citedByCount "120" @default.
• W2034172298 countsByYear W20341722982012 @default.
• W2034172298 countsByYear W20341722982013 @default.
• W2034172298 countsByYear W20341722982014 @default.
• W2034172298 countsByYear W20341722982015 @default.
• W2034172298 countsByYear W20341722982016 @default.
• W2034172298 countsByYear W20341722982017 @default.
• W2034172298 countsByYear W20341722982018 @default.
• W2034172298 countsByYear W20341722982019 @default.
• W2034172298 countsByYear W20341722982020 @default.
• W2034172298 countsByYear W20341722982021 @default.
• W2034172298 countsByYear W20341722982022 @default.
• W2034172298 countsByYear W20341722982023 @default.
• W2034172298 crossrefType "journal-article" @default.
• W2034172298 hasAuthorship W2034172298A5008693707 @default.
• W2034172298 hasAuthorship W2034172298A5029079922 @default.
• W2034172298 hasAuthorship W2034172298A5033903043 @default.
• W2034172298 hasAuthorship W2034172298A5034468485 @default.
• W2034172298 hasAuthorship W2034172298A5045394110 @default.
• W2034172298 hasAuthorship W2034172298A5054858352 @default.
• W2034172298 hasAuthorship W2034172298A5073691282 @default.
• W2034172298 hasAuthorship W2034172298A5080586810 @default.
• W2034172298 hasBestOaLocation W20341722981 @default.
• W2034172298 hasConcept C118441451 @default.
• W2034172298 hasConcept C126322002 @default.
• W2034172298 hasConcept C146403970 @default.
• W2034172298 hasConcept C164705383 @default.
• W2034172298 hasConcept C185263204 @default.
• W2034172298 hasConcept C2776190711 @default.
• W2034172298 hasConcept C2776331378 @default.
• W2034172298 hasConcept C2777796741 @default.
• W2034172298 hasConcept C2778902376 @default.
• W2034172298 hasConcept C2779362680 @default.
• W2034172298 hasConcept C2779703243 @default.
• W2034172298 hasConcept C2780035454 @default.
• W2034172298 hasConcept C2780486423 @default.

• next