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• W2034172434 abstract "Highly active antiretroviral therapy (HAART) has been advocated for the management of primary HIV-1 infection. We investigated the use of a nonnucleoside reverse transcriptase inhibitor (NNRTI)-based regimen in this setting.Twenty-one antiretroviral-naïve individuals with early HIV-1 disease were treated with a combination of efavirenz and Combivir (GlaxoSmithKline, Uxbridge, Middlesex, UK). They were evaluated for immune and lymphocyte function by standard immunological assays.The median time to an undetectable HIV-1 viral load was 12 weeks (range 4-36 weeks). CD4 and CD16/56 counts increased during treatment and CD8 counts decreased minimally. The main side-effects observed were transient sleep disturbances (five patients). In addition, we observed a decrease in lymphocyte activation as assessed by CD38 surface expression.This study demonstrates that primary HIV-1 infection can be treated with NNRTI-based HAART." @default.
• W2034172434 created "2016-06-24" @default.
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• W2034172434 date "2004-01-01" @default.
• W2034172434 modified "2023-09-24" @default.
• W2034172434 title "Treatment of primary HIV-1 infection with nonnucleoside reverse transcriptase inhibitor-based therapy is effective and well tolerated" @default.
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• W2034172434 doi "https://doi.org/10.1111/j.1468-1293.2004.00181.x" @default.
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