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- W2034172518 abstract "Abstract 1. 1. The normal blood sugar level and pancreatic histology, as well as experimental alterations of both, were studied in the salamander, Taricha torosa. 2. 2. The over-all average, normal blood glucose value was found to be 24 mg per cent with an average of 28 mg per cent during the breeding season and 16 mg per cent during estivation. 3. 3. The normal pancreatic islet contains but one type of active endocrine cell, the beta cell. A second type of cell, “clear” cell, exists and is thought to be non-secretory. 4. 4. Glucose, adrenalin and hydrocortisone all produce hyperglycaemia with subsequent beta cell degranulation. 5. 5. Starvation, alloxan, glucagon, Synthalin A and cortisone had no effect on the blood sugar level and produced no specific alterations of the islet cells; one exception to the latter was starvation which caused an eventual atrophy of islet tissue. 6. 6. Insulin resulted in hypoglycaemia even after doses as small as 10 U/kg. Larger doses produced delayed extensor type convulsions, while doses of 1000 U/kg or greater caused both immediate clonic and delayed extensor type convulsions. The only response of the pancreas to insulin was a moderate decrease in beta cell volume. 7. 7. Hypophysectomy resulted in a general decline in the blood sugar level and an eventual atrophy of the pancreatic islets. Pancreatectomy produced a severe hyperglycaemia in the presence or absence of the pituitary gland. Gradual atrophy of the interrenal tissue caused by hypophysectomy was accompanied by a gradual decline in the hyperglycaemic effect of pancreatectomy." @default.
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- W2034172518 date "1960-05-01" @default.
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- W2034172518 title "Studies on the blood glucose and pancreatic islets of the salamander, Taricha torosa" @default.
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- W2034172518 doi "https://doi.org/10.1016/0010-406x(60)90043-8" @default.
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