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- W2034173208 abstract "Nonadherence is a critical issue in transplantation. Recently, Astellas designed a once-daily-extended release formulation of tacrolimus (Tac). Despite initial reports showing bioequivalence of Tac once-daily (Advagraf) with the original formulation requiring twice-daily intake (Tac twice-daily, Prograf), several groups have now shown a sustained decrease in Tac exposure upon conversion from Prograf to Advagraf. Here, we discuss the possible reasons for this observation and how it could affect the expected benefits of Advagraf, and we comment on the fact that a similar lack of bioequivalence might prevail with generic immunosuppressive drugs." @default.
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- W2034173208 date "2012-02-15" @default.
- W2034173208 modified "2023-09-25" @default.
- W2034173208 title "The Once-Daily Formulation of Tacrolimus" @default.
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- W2034173208 doi "https://doi.org/10.1097/tp.0b013e31823aa56e" @default.
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