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• W2034173455 abstract "Background and Objective: Porphyromonas gingivalis fimbriae play a key role in colonization of the oral cavity. The fimA gene, which encodes fimbrillin ( FimA ), can be classified into six types (I–V and Ib) according to nucleotide sequence. In the present study, we investigated the relationship between the prevalence of P. gingivalis ‐specific fimA genotypes and periodontal health status in Chinese adults. Material and Methods: One‐hundred and fifteen patients with chronic periodontitis and 136 periodontally healthy adults were selected. P. gingivalis detection, determination of fimA genotypes, and the co‐existence of Actinobacillus actinomycetemcomitans and Tannerella forsythia with various fimA types, were assessed by the polymerase chain reaction. Odds ratios and 95% confidence intervals were calculated for associating the fimA ‐specific genes with periodontitis. Results: P. gingivalis was detected in 22.1% of healthy subjects and in 81.7% of the patients. A single fimA genotype was detected in most samples. In healthy adults, the most prevalent fimA genotype was type I (66.7%). However, type II was detected most frequently (43.6%) in the patient group, followed by type IV (30.9%). The frequency of co‐existing A. actinomycetemcomitans and T. forsythia was highest in type II fimA ‐positive sites. Statistical analysis revealed that periodontitis was associated with occurrences of type I (odds ratio 0.97), Ib (odds ratio 13.26), II (odds ratio 36.62), III (odds ratio 4.57), IV (odds ratio 22.86) and V (odds ratio 1.19). Conclusion: P. gingivalis type II followed by type IV were considered as disease‐associated strains that account for the pathogenesis of chronic periodontitis in Chinese adults." @default.
• W2034173455 created "2016-06-24" @default.
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• W2034173455 date "2007-07-31" @default.
• W2034173455 modified "2023-10-15" @default.
• W2034173455 title "Prevalence of <i>fimA</i> genotypes of <i>Porphyromonas gingivalis</i> and periodontal health status in Chinese adults" @default.
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• W2034173455 doi "https://doi.org/10.1111/j.1600-0765.2007.00975.x" @default.
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