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• W2034173903 endingPage "3856" @default.
• W2034173903 startingPage "3852" @default.
• W2034173903 abstract "A crucial event in the pathogenesis of systemic enteric virus infections is entry of virus into the nervous system. Whether enteric virus spreads from the intestinal tract to the central nervous system through nerves or through the bloodstream was examined using a serotype 3 reovirus strain. After peroral inoculation of newborn mice with reovirus, serial histologic sections of small intestine, brain and spinal cord were prepared and stained by immunoperoxidase to detect viral antigen. Three days after inoculation, viral antigen was observed in mononuclear cells of ileal Peyer's patches and in neurons of the adjacent myenteric plexus. Infection first appeared in the central nervous system 1-2 days later in neurons of the dorsal motor nucleus of the vagus nerve. Endothelial cells, meninges, choroid plexus, hypothalamus, and area postrema were not infected, indicating neural rather than bloodborne spread from the intestine. Staining of neurons in the dorsal motor nucleus of the vagus nerve depended on the route of virus inoculation and was independent of the amount of virus in the bloodstream. These results demonstrate that an enteric virus entering a host from the intestinal lumen can spread to the central nervous system through nerve fiber innervating the intestine." @default.
• W2034173903 created "2016-06-24" @default.
• W2034173903 creator A5010524054 @default.
• W2034173903 creator A5011296362 @default.
• W2034173903 creator A5014880617 @default.
• W2034173903 date "1991-05-01" @default.
• W2034173903 modified "2023-10-03" @default.
• W2034173903 title "Direct spread of reovirus from the intestinal lumen to the central nervous system through vagal autonomic nerve fibers." @default.
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• W2034173903 doi "https://doi.org/10.1073/pnas.88.9.3852" @default.
• W2034173903 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/51551" @default.
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