FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034173969> ?p ?o ?g. }

• W2034173969 endingPage "8" @default.
• W2034173969 startingPage "1" @default.
• W2034173969 abstract "Artesunate, a remarkable antimalarial agent, also reveals profound cytotoxic activity. In the present investigation, we compared the anticancer effects of artesunate on three colorectal cancer cell lines and analyzed the relationship between drug sensitivity and malignant phenotype of the tumor cells. The findings are as follows: poorly-differentiated was colorectal cancer cell line CLY showing nuclear beta-catenin accumulation and loss of E-cadherin; moderately-differentiated were Lovo cells with cytoplasmic distribution of the two proteins; and well-differentiated were HT-29 cells with membranous localization of them. Also, both in vitro and in vivo, poorly- or moderately-differentiated CLY and Lovo were more susceptible to artesunate treatment than well-differentiated HT-29. Furthermore, the sensitive response of CLY and Lovo to artesunate was associated with membranous translocation of beta-catenin and increased expression of E-cadherin, which indicated the inhibition of hyperactive Wnt signaling pathway and the reversion of the epithelial to mesenchymal transition, respectively. Due to the vital roles of Wnt pathway and the epithelial to mesenchymal transition in tumor differentiation, we thought artesunate could promote the re-differentiation and apoptosis of colorectal cancer cells by inhibition of hyperactive Wnt pathway and reversion of the epithelial to mesenchymal transition." @default.
• W2034173969 created "2016-06-24" @default.
• W2034173969 creator A5012016987 @default.
• W2034173969 creator A5013740618 @default.
• W2034173969 creator A5021844876 @default.
• W2034173969 creator A5028975837 @default.
• W2034173969 creator A5029557558 @default.
• W2034173969 creator A5053275663 @default.
• W2034173969 date "2008-06-01" @default.
• W2034173969 modified "2023-10-03" @default.
• W2034173969 title "Differential sensitivity of colorectal cancer cell lines to artesunate is associated with expression of beta-catenin and E-cadherin" @default.
• W2034173969 cites W1480706413 @default.
• W2034173969 cites W1902021372 @default.
• W2034173969 cites W1964562290 @default.
• W2034173969 cites W1965239527 @default.
• W2034173969 cites W1965410016 @default.
• W2034173969 cites W1967596683 @default.
• W2034173969 cites W1970370517 @default.
• W2034173969 cites W1990671646 @default.
• W2034173969 cites W1993494844 @default.
• W2034173969 cites W1995685700 @default.
• W2034173969 cites W2005476873 @default.
• W2034173969 cites W2009313534 @default.
• W2034173969 cites W2030428837 @default.
• W2034173969 cites W2040373623 @default.
• W2034173969 cites W2040450077 @default.
• W2034173969 cites W2052801384 @default.
• W2034173969 cites W2054288813 @default.
• W2034173969 cites W2054618296 @default.
• W2034173969 cites W2070766958 @default.
• W2034173969 cites W2072955490 @default.
• W2034173969 cites W2086627696 @default.
• W2034173969 cites W2094484000 @default.
• W2034173969 cites W2098184601 @default.
• W2034173969 cites W2101297848 @default.
• W2034173969 cites W2131661896 @default.
• W2034173969 cites W2142777712 @default.
• W2034173969 cites W2148294117 @default.
• W2034173969 cites W2155507705 @default.
• W2034173969 cites W2169111471 @default.
• W2034173969 cites W2171996338 @default.
• W2034173969 cites W4244827160 @default.
• W2034173969 doi "https://doi.org/10.1016/j.ejphar.2008.03.041" @default.
• W2034173969 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18448095" @default.
• W2034173969 hasPublicationYear "2008" @default.
• W2034173969 type Work @default.
• W2034173969 sameAs 2034173969 @default.
• W2034173969 citedByCount "38" @default.
• W2034173969 countsByYear W20341739692012 @default.
• W2034173969 countsByYear W20341739692013 @default.
• W2034173969 countsByYear W20341739692014 @default.
• W2034173969 countsByYear W20341739692015 @default.
• W2034173969 countsByYear W20341739692016 @default.
• W2034173969 countsByYear W20341739692017 @default.
• W2034173969 countsByYear W20341739692018 @default.
• W2034173969 countsByYear W20341739692019 @default.
• W2034173969 countsByYear W20341739692020 @default.
• W2034173969 countsByYear W20341739692021 @default.
• W2034173969 countsByYear W20341739692022 @default.
• W2034173969 countsByYear W20341739692023 @default.
• W2034173969 crossrefType "journal-article" @default.
• W2034173969 hasAuthorship W2034173969A5012016987 @default.
• W2034173969 hasAuthorship W2034173969A5013740618 @default.
• W2034173969 hasAuthorship W2034173969A5021844876 @default.
• W2034173969 hasAuthorship W2034173969A5028975837 @default.
• W2034173969 hasAuthorship W2034173969A5029557558 @default.
• W2034173969 hasAuthorship W2034173969A5053275663 @default.
• W2034173969 hasConcept C104317684 @default.
• W2034173969 hasConcept C121608353 @default.
• W2034173969 hasConcept C126322002 @default.
• W2034173969 hasConcept C127716648 @default.
• W2034173969 hasConcept C137620995 @default.
• W2034173969 hasConcept C154317977 @default.
• W2034173969 hasConcept C185592680 @default.
• W2034173969 hasConcept C190283241 @default.
• W2034173969 hasConcept C202751555 @default.
• W2034173969 hasConcept C203014093 @default.
• W2034173969 hasConcept C2778048844 @default.
• W2034173969 hasConcept C2778059366 @default.
• W2034173969 hasConcept C2778371730 @default.
• W2034173969 hasConcept C2779013556 @default.
• W2034173969 hasConcept C30145163 @default.
• W2034173969 hasConcept C502942594 @default.
• W2034173969 hasConcept C526805850 @default.
• W2034173969 hasConcept C54355233 @default.
• W2034173969 hasConcept C55493867 @default.
• W2034173969 hasConcept C62478195 @default.
• W2034173969 hasConcept C70883133 @default.
• W2034173969 hasConcept C71924100 @default.
• W2034173969 hasConcept C76419328 @default.
• W2034173969 hasConcept C81885089 @default.
• W2034173969 hasConcept C86803240 @default.
• W2034173969 hasConcept C95444343 @default.
• W2034173969 hasConceptScore W2034173969C104317684 @default.
• W2034173969 hasConceptScore W2034173969C121608353 @default.
• W2034173969 hasConceptScore W2034173969C126322002 @default.
• W2034173969 hasConceptScore W2034173969C127716648 @default.
• W2034173969 hasConceptScore W2034173969C137620995 @default.

• next