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- W2034174512 abstract "A compartmental model of copper metabolism in adult men was developed from stable isotope data obtained in a 90-day study during which three levels of dietary copper (1.68, 0.785, 7.52 mg/d) were fed. The tracer 65Cu was administered intravenously (i.v.) three times and orally four times during the study period. The model contains five compartments, two delay components, and two excretion pathways interpreted as two plasma compartments, two liver compartments, an other-tissue compartment, and fecal and urinary excretion routes. Dietary copper level influences the flow from the second liver compartment to the second plasma compartment and from the second plasma compartment to the other-tissues compartment. The model suggests that the tissue uptake of oral and i.v. copper is different, with flow from plasma to the first liver compartment varying with route of isotopic administration. The model-predicted masses of copper within the compartments and delay components follow a pattern of expected masses within the body. The major storage sites predicted are the second liver compartment, the delay after the other-tissue compartment, and the delay in the fecal excretion pathway. The model predicts that 65% of plasma copper is bound to ceruloplasmin, compared with 56 to 68% calculated from the data. Approximately 4.1 ± 0.8% of total body copper was predicted to be in plasma compared with 2 to 6% expected." @default.
- W2034174512 created "2016-06-24" @default.
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- W2034174512 date "1994-07-01" @default.
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- W2034174512 title "Compartmental model of copper metabolism in adult men," @default.
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- W2034174512 doi "https://doi.org/10.1016/0955-2863(94)90064-7" @default.
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