FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034174652> ?p ?o ?g. }

• W2034174652 endingPage "1977" @default.
• W2034174652 startingPage "1967" @default.
• W2034174652 abstract "The fibrocartilaginous menisci are load-bearing tissues vital to the normal functioning of the knee. Removal of damaged regions of the meniscus subsequent to injury impairs knee function and predisposes patients to osteoarthritis. In this study, we employed biodegradable nanofibrous scaffolds for the tissue engineering of the meniscus. Non-aligned (NA) or fiber-aligned (AL) nanofibrous scaffolds were seeded with meniscal fibrochondrocytes (MFCs) or mesenchymal stem cells (MSCs) to test the hypothesis that fiber-alignment would augment matrix content and organization, resulting in improved mechanical properties. Additionally, we proposed that MSCs could serve as an alternative to MFCs. With time in culture, MSC- and MFC-seeded NA and AL constructs increased in cellularity and extracellular matrix (ECM) content. Counter our initial hypothesis, NA and AL constructs contained comparable amounts of ECM, although a significantly larger increase in mechanical properties was observed for AL compared to NA constructs seeded with either cell type. Cell-seeded NA constructs increased in modulus by approximately 1MPa over 10 weeks while cell-seeded AL construct increased by >7MPa. Additionally, MSC-constructs yielded greater amounts of ECM and demonstrated comparable increases in mechanical properties, thereby confirming the utility of MSCs for meniscus tissue engineering. These results demonstrate that cell-seeded fiber-aligned nanofibrous scaffolds may serve as an instructive micro-pattern for directed tissue growth, reconstituting both the form and function of the native tissue." @default.
• W2034174652 created "2016-06-24" @default.
• W2034174652 creator A5018983636 @default.
• W2034174652 creator A5069952936 @default.
• W2034174652 date "2007-04-01" @default.
• W2034174652 modified "2023-10-13" @default.
• W2034174652 title "The effect of nanofiber alignment on the maturation of engineered meniscus constructs" @default.
• W2034174652 cites W1481696013 @default.
• W2034174652 cites W1485073457 @default.
• W2034174652 cites W1970102846 @default.
• W2034174652 cites W1972766239 @default.
• W2034174652 cites W1976236115 @default.
• W2034174652 cites W1978122014 @default.
• W2034174652 cites W1986203261 @default.
• W2034174652 cites W1993895799 @default.
• W2034174652 cites W1998869888 @default.
• W2034174652 cites W2005484961 @default.
• W2034174652 cites W2019575274 @default.
• W2034174652 cites W2026547102 @default.
• W2034174652 cites W2027736364 @default.
• W2034174652 cites W2028291660 @default.
• W2034174652 cites W2029259783 @default.
• W2034174652 cites W2032255522 @default.
• W2034174652 cites W2032913221 @default.
• W2034174652 cites W2039954098 @default.
• W2034174652 cites W2044929399 @default.
• W2034174652 cites W2047256363 @default.
• W2034174652 cites W2055630021 @default.
• W2034174652 cites W2059139436 @default.
• W2034174652 cites W2062279390 @default.
• W2034174652 cites W2065083955 @default.
• W2034174652 cites W2068427400 @default.
• W2034174652 cites W2070031476 @default.
• W2034174652 cites W2072751809 @default.
• W2034174652 cites W2074266529 @default.
• W2034174652 cites W2082510662 @default.
• W2034174652 cites W2082712298 @default.
• W2034174652 cites W2084123923 @default.
• W2034174652 cites W2084611965 @default.
• W2034174652 cites W2089932886 @default.
• W2034174652 cites W2091695131 @default.
• W2034174652 cites W2097922419 @default.
• W2034174652 cites W2111296762 @default.
• W2034174652 cites W2112275933 @default.
• W2034174652 cites W2130806884 @default.
• W2034174652 cites W2136870096 @default.
• W2034174652 cites W2141420021 @default.
• W2034174652 cites W2142417187 @default.
• W2034174652 cites W2147765604 @default.
• W2034174652 cites W2156382870 @default.
• W2034174652 cites W2159999899 @default.
• W2034174652 cites W2169391121 @default.
• W2034174652 cites W2190417539 @default.
• W2034174652 cites W2334597378 @default.
• W2034174652 cites W2419424494 @default.
• W2034174652 cites W298340976 @default.
• W2034174652 doi "https://doi.org/10.1016/j.biomaterials.2007.01.004" @default.
• W2034174652 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1847368" @default.
• W2034174652 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17250888" @default.
• W2034174652 hasPublicationYear "2007" @default.
• W2034174652 type Work @default.
• W2034174652 sameAs 2034174652 @default.
• W2034174652 citedByCount "335" @default.
• W2034174652 countsByYear W20341746522012 @default.
• W2034174652 countsByYear W20341746522013 @default.
• W2034174652 countsByYear W20341746522014 @default.
• W2034174652 countsByYear W20341746522015 @default.
• W2034174652 countsByYear W20341746522016 @default.
• W2034174652 countsByYear W20341746522017 @default.
• W2034174652 countsByYear W20341746522018 @default.
• W2034174652 countsByYear W20341746522019 @default.
• W2034174652 countsByYear W20341746522020 @default.
• W2034174652 countsByYear W20341746522021 @default.
• W2034174652 countsByYear W20341746522022 @default.
• W2034174652 countsByYear W20341746522023 @default.
• W2034174652 crossrefType "journal-article" @default.
• W2034174652 hasAuthorship W2034174652A5018983636 @default.
• W2034174652 hasAuthorship W2034174652A5069952936 @default.
• W2034174652 hasBestOaLocation W20341746522 @default.
• W2034174652 hasConcept C105702510 @default.
• W2034174652 hasConcept C106487976 @default.
• W2034174652 hasConcept C120665830 @default.
• W2034174652 hasConcept C121332964 @default.
• W2034174652 hasConcept C12554922 @default.
• W2034174652 hasConcept C136229726 @default.
• W2034174652 hasConcept C142724271 @default.
• W2034174652 hasConcept C159985019 @default.
• W2034174652 hasConcept C171250308 @default.
• W2034174652 hasConcept C189165786 @default.
• W2034174652 hasConcept C189178095 @default.
• W2034174652 hasConcept C192562407 @default.
• W2034174652 hasConcept C198826908 @default.
• W2034174652 hasConcept C204787440 @default.
• W2034174652 hasConcept C2776164576 @default.
• W2034174652 hasConcept C2780550940 @default.
• W2034174652 hasConcept C49892992 @default.
• W2034174652 hasConcept C61511704 @default.
• W2034174652 hasConcept C71924100 @default.

• next