FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034175553> ?p ?o ?g. }

• W2034175553 endingPage "2127" @default.
• W2034175553 startingPage "2120" @default.
• W2034175553 abstract "Background— Although CD73/ecto-5′-nucleotidase has been implicated in maintaining vasoprotection, its role in regulating endothelial adhesion molecule or inflammatory monocyte recruitment (eg, in the context of vascular injury) remains to be defined. Methods and Results— Compared with wild-type mice, CD73-deficient (CD73 −/− ) mice exhibit increased luminal staining and protein and transcript expression for vascular cell adhesion molecule (VCAM)-1 in carotid arteries. In vitro, aortic endothelial cells (ECs) from CD73 −/− mice display an upregulation of mRNA and protein expression of VCAM-1, associated with increased nuclear factor (NF)-κB activity, as determined by chromatin cross-linking and immunoprecipitation or quantitative p65 binding assays. CD73 −/− ECs and carotid arteries perfused ex vivo supported increased monocyte arrest under flow conditions, which was mediated by α 4β1 integrin. After wire injury of carotid arteries, CD73 expression and activity were upregulated in wild-type mice, whereas neointimal plaque formation and macrophage content were increased in CD73 −/− mice versus wild-type mice, concomitant with elevated NF-κB activation, luminal VCAM-1 expression, and soluble VCAM-1 concentrations. In contrast, reconstitution of wild-type mice with CD73 −/− versus CD73 +/+ BM did not significantly exacerbate neointima formation. Treatment with the specific A 2A receptor agonist ATL-146e reversed the increased VCAM-1 transcript and protein expression in CD73 −/− ECs and inhibited monocyte arrest on CD73 −/− ECs. Continuous infusion of ATL-146e prevented neointima formation in CD73 −/− mice. Conclusions— Our data epitomize the importance of vascular CD73 in limiting endothelial activation and monocyte recruitment via generation of adenosine acting through the A 2A receptor, providing a molecular basis for therapeutic protection against vascular inflammation and neointimal hyperplasia." @default.
• W2034175553 created "2016-06-24" @default.
• W2034175553 creator A5001883769 @default.
• W2034175553 creator A5003007188 @default.
• W2034175553 creator A5017760830 @default.
• W2034175553 creator A5025755070 @default.
• W2034175553 creator A5042328259 @default.
• W2034175553 creator A5046954868 @default.
• W2034175553 creator A5057582462 @default.
• W2034175553 creator A5089768561 @default.
• W2034175553 creator A5090315796 @default.
• W2034175553 date "2006-05-02" @default.
• W2034175553 modified "2023-10-11" @default.
• W2034175553 title "CD73/Ecto-5′-Nucleotidase Protects Against Vascular Inflammation and Neointima Formation" @default.
• W2034175553 cites W107632664 @default.
• W2034175553 cites W1575186397 @default.
• W2034175553 cites W1792542720 @default.
• W2034175553 cites W1814667993 @default.
• W2034175553 cites W2003641968 @default.
• W2034175553 cites W2020809562 @default.
• W2034175553 cites W2049902401 @default.
• W2034175553 cites W2066963386 @default.
• W2034175553 cites W2077119701 @default.
• W2034175553 cites W2094706674 @default.
• W2034175553 cites W2097176818 @default.
• W2034175553 cites W2098155709 @default.
• W2034175553 cites W2101444839 @default.
• W2034175553 cites W2108067308 @default.
• W2034175553 cites W2133068443 @default.
• W2034175553 cites W2139319526 @default.
• W2034175553 cites W2162003329 @default.
• W2034175553 cites W2166028130 @default.
• W2034175553 cites W2166798770 @default.
• W2034175553 cites W2254834000 @default.
• W2034175553 cites W2615751376 @default.
• W2034175553 doi "https://doi.org/10.1161/circulationaha.105.595249" @default.
• W2034175553 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16636171" @default.
• W2034175553 hasPublicationYear "2006" @default.
• W2034175553 type Work @default.
• W2034175553 sameAs 2034175553 @default.
• W2034175553 citedByCount "133" @default.
• W2034175553 countsByYear W20341755532012 @default.
• W2034175553 countsByYear W20341755532013 @default.
• W2034175553 countsByYear W20341755532014 @default.
• W2034175553 countsByYear W20341755532015 @default.
• W2034175553 countsByYear W20341755532016 @default.
• W2034175553 countsByYear W20341755532017 @default.
• W2034175553 countsByYear W20341755532018 @default.
• W2034175553 countsByYear W20341755532019 @default.
• W2034175553 countsByYear W20341755532020 @default.
• W2034175553 countsByYear W20341755532021 @default.
• W2034175553 countsByYear W20341755532022 @default.
• W2034175553 crossrefType "journal-article" @default.
• W2034175553 hasAuthorship W2034175553A5001883769 @default.
• W2034175553 hasAuthorship W2034175553A5003007188 @default.
• W2034175553 hasAuthorship W2034175553A5017760830 @default.
• W2034175553 hasAuthorship W2034175553A5025755070 @default.
• W2034175553 hasAuthorship W2034175553A5042328259 @default.
• W2034175553 hasAuthorship W2034175553A5046954868 @default.
• W2034175553 hasAuthorship W2034175553A5057582462 @default.
• W2034175553 hasAuthorship W2034175553A5089768561 @default.
• W2034175553 hasAuthorship W2034175553A5090315796 @default.
• W2034175553 hasBestOaLocation W20341755531 @default.
• W2034175553 hasConcept C104317684 @default.
• W2034175553 hasConcept C126322002 @default.
• W2034175553 hasConcept C127561419 @default.
• W2034175553 hasConcept C134018914 @default.
• W2034175553 hasConcept C185592680 @default.
• W2034175553 hasConcept C2776914184 @default.
• W2034175553 hasConcept C2776992346 @default.
• W2034175553 hasConcept C2777339539 @default.
• W2034175553 hasConcept C2778283817 @default.
• W2034175553 hasConcept C2778583881 @default.
• W2034175553 hasConcept C2781184567 @default.
• W2034175553 hasConcept C55493867 @default.
• W2034175553 hasConcept C71924100 @default.
• W2034175553 hasConcept C86803240 @default.
• W2034175553 hasConcept C95444343 @default.
• W2034175553 hasConceptScore W2034175553C104317684 @default.
• W2034175553 hasConceptScore W2034175553C126322002 @default.
• W2034175553 hasConceptScore W2034175553C127561419 @default.
• W2034175553 hasConceptScore W2034175553C134018914 @default.
• W2034175553 hasConceptScore W2034175553C185592680 @default.
• W2034175553 hasConceptScore W2034175553C2776914184 @default.
• W2034175553 hasConceptScore W2034175553C2776992346 @default.
• W2034175553 hasConceptScore W2034175553C2777339539 @default.
• W2034175553 hasConceptScore W2034175553C2778283817 @default.
• W2034175553 hasConceptScore W2034175553C2778583881 @default.
• W2034175553 hasConceptScore W2034175553C2781184567 @default.
• W2034175553 hasConceptScore W2034175553C55493867 @default.
• W2034175553 hasConceptScore W2034175553C71924100 @default.
• W2034175553 hasConceptScore W2034175553C86803240 @default.
• W2034175553 hasConceptScore W2034175553C95444343 @default.
• W2034175553 hasIssue "17" @default.
• W2034175553 hasLocation W20341755531 @default.
• W2034175553 hasLocation W20341755532 @default.
• W2034175553 hasOpenAccess W2034175553 @default.
• W2034175553 hasPrimaryLocation W20341755531 @default.

• next