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• W2034176319 endingPage "96" @default.
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• W2034176319 abstract "miR-21 is overexpressed in tumors and it displays oncogenic activity. Here, we show that expression of miR-21 in primary tumors anticorrelates with KRIT1/CCM1, an interacting partner of the Ras-like GTPase Rap1, involved in Cerebral Cavernous Malformations (CCM). We present evidences that miR-21 silences KRIT1 by targeting its mRNA 3′UTR and that this interaction is involved in tumor growth control. In fact, miR-21 over-expression or KRIT1 knock-down promote anchorage independent tumor cell growth compared to controls, whereas the opposite is observed when anti-miR-21 or KRIT1 overexpression are employed. Our findings suggest that miR-21 promotes tumor cell growth, at least in part, by down-modulating the potential tumor suppressor KRIT1." @default.
• W2034176319 created "2016-06-24" @default.
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• W2034176319 date "2013-08-01" @default.
• W2034176319 modified "2023-09-26" @default.
• W2034176319 title "miR-21 coordinates tumor growth and modulates KRIT1 levels" @default.
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• W2034176319 doi "https://doi.org/10.1016/j.bbrc.2013.07.031" @default.
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