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- W2034176400 abstract "Abstract The interactions of 2-amino-6-methyldipyrido[1,2-a:3′,2′-d]imidazole (Glu-P-1) and its analog 2-amino-dipyrido[1,2-a:3′,2′-d]imidazole (Glu-P-2) which are potent mutagens isolated from a L-glutamic acid pyrolysate, with calf thymus DNA were studied spectroscopically. Scatchard plots obtained by optical titration gave association constants, K, of 2.7 ∼ 17 × 10 3 M −1 for several derivatives. Flow dichroism studies showed that Glu-P-1 and other derivatives are oriented in parallel to the planes of base pairs of DNA. The correlation between the association constants and degrees of mutagenicity is discussed." @default.
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- W2034176400 date "1980-09-01" @default.
- W2034176400 modified "2023-09-24" @default.
- W2034176400 title "Non-covalent interaction with DNA of the mutagens 2-amino-dipyrido[1,2-a:3′,2′-d]imidazole and methyl-substituted isomers" @default.
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- W2034176400 doi "https://doi.org/10.1016/0006-291x(80)91399-6" @default.
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