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- W2034178811 abstract "Autotaxin (ATX) is a secreted enzyme with lysophospholipase D (lysoPLD) activity, which converts lysophosphatidylcholine (LPC) into lysophosphatidic acid (LPA), a bioactive phospholipid involved in numerous biological activities, including cell proliferation, differentiation, and migration. In the present study, we found that bacterial lipopolysaccharide (LPS), a well-known initiator of the inflammatory response, induced ATX expression in monocytic THP-1 cells. The activation of PKR, JNK, and p38 MAPK was required for the ATX induction. The LPS-induced ATX in THP-1 cells was characterized as the beta isoform. In the presence of LPC, ATX could promote the migrations of THP-1 and Jurkat cells, which was inhibited by pertussis toxin (PTX), an inhibitor of Gi-mediated LPA receptor signaling. In summary, LPS induces ATX expression in THP-1 cells via a PKR, JNK and p38 MAPK-mediated mechanism, and the ATX induction is likely to enhance immune cell migration in proinflammatory response by regulating LPA levels in the microenvironment." @default.
- W2034178811 created "2016-06-24" @default.
- W2034178811 creator A5081615766 @default.
- W2034178811 creator A5090439768 @default.
- W2034178811 date "2009-01-01" @default.
- W2034178811 modified "2023-10-10" @default.
- W2034178811 title "Lipopolysaccharide induces autotaxin expression in human monocytic THP-1 cells" @default.
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- W2034178811 doi "https://doi.org/10.1016/j.bbrc.2008.11.047" @default.
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