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• W2034178825 startingPage "130" @default.
• W2034178825 abstract "The skin has to effectively combat external attacks, while maintaining skin immune homeostasis under steady-state conditions. To fulfill these challenging tasks, the dermis harbors a variety of heterogeneous cell types that are able to suppress T-cell proliferation similar to bone marrow mesenchymal stromal cells. Here we show that plastic-adherent, human dermal cells induce FoxP3 expression in TCR-complex–stimulated CD25−CD4+CD45RA+ T cells in the absence of CD28 co-ligation in a cell-contact–dependent manner. These FoxP3+ T cells reveal an effective suppressive capacity in vitro. Moreover, we found that the vast majority of CD90+ dermal cells are perivascularly located and generate a significantly higher percentage of regulatory T cells compared with cells expressing markers such as CD271 in vitro. Importantly, we further demonstrate that plastic-adherent dermal cells are also able to differentiate toward the endothelial lineage. Our data show that human skin harbors specific cell types with immunosuppressive potential, which are located in close vicinity to their likely operational area and provide evidence for a CD28-independent regulatory mechanism. Further, the differentiation potential into endothelial cells suggests the existence of a tissue-resident cell pool for vessel regeneration. These findings might have important implications for the clinical use of allogeneic dermal cells to rebuild an imbalanced human skin immune homeostasis. The skin has to effectively combat external attacks, while maintaining skin immune homeostasis under steady-state conditions. To fulfill these challenging tasks, the dermis harbors a variety of heterogeneous cell types that are able to suppress T-cell proliferation similar to bone marrow mesenchymal stromal cells. Here we show that plastic-adherent, human dermal cells induce FoxP3 expression in TCR-complex–stimulated CD25−CD4+CD45RA+ T cells in the absence of CD28 co-ligation in a cell-contact–dependent manner. These FoxP3+ T cells reveal an effective suppressive capacity in vitro. Moreover, we found that the vast majority of CD90+ dermal cells are perivascularly located and generate a significantly higher percentage of regulatory T cells compared with cells expressing markers such as CD271 in vitro. Importantly, we further demonstrate that plastic-adherent dermal cells are also able to differentiate toward the endothelial lineage. Our data show that human skin harbors specific cell types with immunosuppressive potential, which are located in close vicinity to their likely operational area and provide evidence for a CD28-independent regulatory mechanism. Further, the differentiation potential into endothelial cells suggests the existence of a tissue-resident cell pool for vessel regeneration. These findings might have important implications for the clinical use of allogeneic dermal cells to rebuild an imbalanced human skin immune homeostasis. antigen-presenting cell bone marrow forkhead box P3 human embryonic kidney cells latency-associated protein mesenchymal stromal cell transforming growth factor-β regulatory T cell" @default.
• W2034178825 created "2016-06-24" @default.
• W2034178825 creator A5021114812 @default.
• W2034178825 creator A5031726040 @default.
• W2034178825 creator A5069818904 @default.
• W2034178825 creator A5071273682 @default.
• W2034178825 date "2015-01-01" @default.
• W2034178825 modified "2023-10-15" @default.
• W2034178825 title "CD90 + Human Dermal Stromal Cells Are Potent Inducers of FoxP3 + Regulatory T Cells" @default.
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• W2034178825 doi "https://doi.org/10.1038/jid.2014.309" @default.
• W2034178825 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25050599" @default.
• W2034178825 hasPublicationYear "2015" @default.
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