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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034178954> ?p ?o ?g. }

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• W2034178954 abstract "Fused dihydroindazolopyrrolocarbazole oximes have been identified as low nanomolar, potent dual TIE-2 and VEGF-R2 receptor tyrosine kinase inhibitors with excellent cellular potency. Development of the structure-activity relationships (SAR) led to identification of compounds 35 and 40 as potent, selective dual TIE-2/VEGF-R2 inhibitors with favorable pharmacokinetic properties. Compound 35 was orally active in tumor models with no observed toxicity." @default.
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• W2034178954 date "2008-03-01" @default.
• W2034178954 modified "2023-09-28" @default.
• W2034178954 title "Design and synthesis of dihydroindazolo[5,4-a]pyrrolo[3,4-c]carbazole oximes as potent dual inhibitors of TIE-2 and VEGF-R2 receptor tyrosine kinases" @default.
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• W2034178954 doi "https://doi.org/10.1016/j.bmcl.2008.02.001" @default.
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