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- W2034181033 abstract "Prions are self-propagating proteinaceous infectious agents capable of transmitting disease in the absence of nucleic acids. The nature of the infectious agent in prion diseases has been at the center of passionate debate for the past 30 years. However, recent reports on the in vitro generation of prions have settled all doubts that the misfolded prion protein (PrPSc) is the key component in propagating infectivity. However, we still do not understand completely the mechanism of prion replication and whether or not other cellular factors besides PrPSc are required for infectivity. In this article, we discuss these recent reports under the context of the protein-only hypothesis and their implications." @default.
- W2034181033 created "2016-06-24" @default.
- W2034181033 creator A5073301223 @default.
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- W2034181033 date "2010-04-01" @default.
- W2034181033 modified "2023-09-24" @default.
- W2034181033 title "Generation of prions in vitro and the protein-only hypothesis" @default.
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- W2034181033 doi "https://doi.org/10.4161/pri.4.2.11960" @default.
- W2034181033 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2933051" @default.
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