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• W2034182822 endingPage "e0121903" @default.
• W2034182822 startingPage "e0121903" @default.
• W2034182822 abstract "Background Diagnosis of fibromyalgia (FM), a chronic musculoskeletal pain syndrome characterized by generalized body pain, hyperalgesia and other functional and emotional comorbidities, is a challenging process hindered by symptom heterogeneity and clinical overlap with other disorders. No objective diagnostic method exists at present. The aim of this study was to identify changes in miRNA expression profiles (miRNome) of these patients for the development of a quantitative diagnostic method of FM. In addition, knowledge of FM patient miRNomes should lead to a deeper understanding of the etiology and/or symptom severity of this complex disease. Methods Genome-wide expression profiling of miRNAs was assessed in Peripheral Blood Mononuclear Cells (PBMCs) of FM patients (N=11) and population-age-matched controls (N=10) using human v16-miRbase 3D-Gene microarrays (Toray Industries, Japan). Selected miRNAs from the screen were further validated by RT-qPCR. Participating patients were long term sufferers (over 10 years) diagnosed by more than one specialist under 1990 American College of Rheumatology criteria. Results Microarray analysis of FM patient PBMCs evidenced a marked downregulation of hsa-miR223-3p, hsa-miR451a, hsa-miR338-3p, hsa-miR143-3p, hsa-miR145-5p and hsa-miR-21-5p (4-fold or more). All but the mildest inhibited miRNA, hsa-miR-21-5p, were validated by RT-qPCR. Globally, 20% of the miRNAs analyzed (233/1212) showed downregulation of at least 2-fold in patients. This might indicate a general de-regulation of the miRNA synthetic pathway in FM. No significant correlations between miRNA inhibition and FM cardinal symptoms could be identified. However, the patient with the lowest score for mental fatigue coincided with the mildest inhibition in four of the five miRNAs associated with the FM-group. Conclusions We propose a signature of five strikingly downregulated miRNAs (hsa-miR223-3p, hsa-miR451a, hsa-miR338-3p, hsa-miR143-3p and hsa-miR145-5p) to be used as biomarkers of FM. Validation in larger study groups is required before the results can be transferred to the clinic." @default.
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• W2034182822 date "2015-03-24" @default.
• W2034182822 modified "2023-10-17" @default.
• W2034182822 title "Identification of a MicroRNA Signature for the Diagnosis of Fibromyalgia" @default.
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• W2034182822 cites W1950256523 @default.
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• W2034182822 cites W1975319407 @default.
• W2034182822 cites W1975437957 @default.
• W2034182822 cites W1985498551 @default.
• W2034182822 cites W1987414543 @default.
• W2034182822 cites W1994362859 @default.
• W2034182822 cites W1998146142 @default.
• W2034182822 cites W1999943971 @default.
• W2034182822 cites W2003239266 @default.
• W2034182822 cites W2010923045 @default.
• W2034182822 cites W2011943543 @default.
• W2034182822 cites W2020541351 @default.
• W2034182822 cites W2025564038 @default.
• W2034182822 cites W2026087575 @default.
• W2034182822 cites W2028994878 @default.
• W2034182822 cites W2033556122 @default.
• W2034182822 cites W2036246029 @default.
• W2034182822 cites W2036709667 @default.
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• W2034182822 cites W2072565675 @default.
• W2034182822 cites W2073231720 @default.
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• W2034182822 doi "https://doi.org/10.1371/journal.pone.0121903" @default.
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