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- W2034183183 abstract "Epithelial cells from enzymically dispersed seminal vesicle tissue of castrated adult rats were grown on collagen-coated surfaces in serum-containing medium for up to 6 weeks. Androgens were neither required for growth nor were they mitogenic. They also failed to induce the synthesis of tissue-specific secretory proteins that serve as markers of androgen action in vivo. A variety of potential growth factors and culture procedures (such as feeder layers, extracellular matrices, collagen gels, and growth from tissue explants) were examined for their ability to support androgen action. Testosterone and 5 alpha-dihydrotestosterone were only able to induce seminal vesicle secretory protein synthesis in the presence of neurotransmitters (acetylcholine, noradrenaline, or serotonin). The mechanism of this permissive effect of neurotransmitters on androgenic induction has been examined. It is not related to their mitogenic activity since other mitogens (epidermal growth factor and corticosterone) did not facilitate androgen action. Agents that raise intracellular cAMP were also ineffective so cAMP is probably not involved, but the phosphatidyl inositol pathway may be important." @default.
- W2034183183 created "2016-06-24" @default.
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- W2034183183 date "1987-11-01" @default.
- W2034183183 modified "2023-09-26" @default.
- W2034183183 title "Growth of Rat Seminal Vesicle Epithelial Cells in Culture: Neurotransmitters Are Required for Androgen-Regulated Synthesis of Tissue-Specific Secretory Proteins*" @default.
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- W2034183183 doi "https://doi.org/10.1210/endo-121-5-1678" @default.
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