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- W2034183892 abstract "In this study, the short component of the 23Na T2 (T2f) and the 23Na and 2H quadrupolar interactions (νQ) were measured in bone-cartilage samples of osteoarthritic (OA) and osteoporotic (OP) patients. 23Na νQ was found to increase in osteoarthritic articular cartilage relative to controls. Similar results were found in bovine cartilage following proteoglycan (PG) depletion, a condition that prevails in osteoarthritis. 23Na νQ and 1/T2f for articular cartilage obtained from osteoporotic patients were significantly larger than for control and osteoarthritic cartilage. Decalcification of both human and bovine articular cartilage resulted in an increase of 23Na νQ and 1/T2f, showing the same trend as the osteoporotic samples. Differences in the ratio of the intensity of the large 2H splitting to that of the small one in the calcified zone were also observed. In osteoporosis, this ratio was twice as large as that obtained for both control and osteoarthritic samples. The 2H and 23Na results can be interpreted as due to sodium ions and water molecules filling the void created by the calcium depletion and to calcium ions being located in close association with the collagen fibers. To the best of our knowledge, this is the first study reporting differences of NMR parameters in cartilage of osteoporotic patients. Magn Reson Med, 2010. © 2010 Wiley-Liss, Inc." @default.
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- W2034183892 date "2010-08-25" @default.
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- W2034183892 title "23Na and 2H magnetic resonance studies of osteoarthritic and osteoporotic articular cartilage" @default.
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- W2034183892 doi "https://doi.org/10.1002/mrm.22479" @default.
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