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- W2034184460 abstract "We have studied the thyroid-hormone responsiveness of the alpha-myosin heavy chain (MHC) gene in vivo by directly injecting an expression vector containing the alpha-MHC 5′ regulatory sequences (−613 to +421 base pairs) into the rat heart. In the expression vector pAM1Luc the alpha-MHC promoter elements direct the synthesis of firefly luciferase. Although thyroxine administration of both euthyroid and thyroidectomized rats for 5 days increased alpha-MHC promoter activity, the pAM1Luc gene construct did not mimic expression of the endogenous gene. These studies of direct gene transfer into mammalian myocardium suggest that additional cis-acting elements necessary for the in vivo response to thyroid hormone reside outside the −613 to +421 region." @default.
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- W2034184460 date "1991-09-01" @default.
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- W2034184460 title "Thyroid hormone regulation of alpha-myosin heavy chain promoter activity assessed by invivo DNA transfer in rat heart" @default.
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- W2034184460 doi "https://doi.org/10.1016/0006-291x(91)91710-t" @default.
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