FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034184579> ?p ?o ?g. }

• W2034184579 endingPage "2365" @default.
• W2034184579 startingPage "2357" @default.
• W2034184579 abstract "Elevated homocysteine levels are defined as hyperhomocysteinemia (HHcy), a disorder that is associated with cardiovascular and neurodegenerative diseases as well as with hepatic fibrosis. Recent studies have shown that HHcy promotes hepatic injury by increasing oxidative stress. Although homocysteine induces cell cycle arrest in a variety of different cell types, it is not known whether HHcy has a definitive role in hepatocyte proliferation during liver regeneration. In this report, we investigated the effect of homocysteine on liver regeneration. Our results demonstrated that mice with HHcy exhibited an impairment in liver regeneration after partial hepatectomy, as measured by immunohistochemical staining of proliferation cell nuclear antigen and bromodeoxyuridine incorporation. Impaired proliferation was also correlated with reduced cyclin D1 induction and elevated expression levels of both p53 and p21Cip1. In addition, the phosphorylation of Akt, which plays an essential role in normal regeneration responses, was attenuated during the early phases of liver regeneration in HHcy mice. Our results also indicated that the cAMP/protein kinase A pathway mediated the inhibitory effect of homocysteine on liver regeneration. These findings provide evidence that impairment of liver regeneration by HHcy may result in delayed recovery from liver injury induced by homocysteine itself." @default.
• W2034184579 created "2016-06-24" @default.
• W2034184579 creator A5008575045 @default.
• W2034184579 creator A5009076376 @default.
• W2034184579 creator A5018201691 @default.
• W2034184579 creator A5045779549 @default.
• W2034184579 creator A5049119597 @default.
• W2034184579 creator A5067451569 @default.
• W2034184579 creator A5077231720 @default.
• W2034184579 date "2010-11-01" @default.
• W2034184579 modified "2023-09-24" @default.
• W2034184579 title "Hepatocyte Proliferation During Liver Regeneration Is Impaired in Mice with Methionine Diet-Induced Hyperhomocysteinemia" @default.
• W2034184579 cites W1964209362 @default.
• W2034184579 cites W1968994944 @default.
• W2034184579 cites W1970735844 @default.
• W2034184579 cites W1973261871 @default.
• W2034184579 cites W1974207791 @default.
• W2034184579 cites W1979895785 @default.
• W2034184579 cites W1979950901 @default.
• W2034184579 cites W1984258364 @default.
• W2034184579 cites W1984418041 @default.
• W2034184579 cites W1985072621 @default.
• W2034184579 cites W1988290861 @default.
• W2034184579 cites W1992679814 @default.
• W2034184579 cites W1992864367 @default.
• W2034184579 cites W2000595541 @default.
• W2034184579 cites W2014468331 @default.
• W2034184579 cites W2025106039 @default.
• W2034184579 cites W2025945219 @default.
• W2034184579 cites W2026389696 @default.
• W2034184579 cites W2027217537 @default.
• W2034184579 cites W2028879048 @default.
• W2034184579 cites W2033811034 @default.
• W2034184579 cites W2034639072 @default.
• W2034184579 cites W2038593831 @default.
• W2034184579 cites W2041044388 @default.
• W2034184579 cites W2042071773 @default.
• W2034184579 cites W2051019972 @default.
• W2034184579 cites W2051844808 @default.
• W2034184579 cites W2052588755 @default.
• W2034184579 cites W2056739101 @default.
• W2034184579 cites W2062378136 @default.
• W2034184579 cites W2064412900 @default.
• W2034184579 cites W2065170506 @default.
• W2034184579 cites W2066542032 @default.
• W2034184579 cites W2080120151 @default.
• W2034184579 cites W2090087259 @default.
• W2034184579 cites W2092288031 @default.
• W2034184579 cites W2099061565 @default.
• W2034184579 cites W2103364760 @default.
• W2034184579 cites W2103873678 @default.
• W2034184579 cites W2108577593 @default.
• W2034184579 cites W2126230337 @default.
• W2034184579 cites W2137234652 @default.
• W2034184579 cites W2138532578 @default.
• W2034184579 cites W2138701341 @default.
• W2034184579 cites W2140455030 @default.
• W2034184579 cites W2140483277 @default.
• W2034184579 cites W2141202023 @default.
• W2034184579 cites W2150332624 @default.
• W2034184579 cites W2154615092 @default.
• W2034184579 cites W2159964903 @default.
• W2034184579 cites W2163168736 @default.
• W2034184579 cites W2166342119 @default.
• W2034184579 cites W2169425069 @default.
• W2034184579 cites W2170053577 @default.
• W2034184579 cites W4237329722 @default.
• W2034184579 doi "https://doi.org/10.2353/ajpath.2010.091131" @default.
• W2034184579 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2966794" @default.
• W2034184579 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20864682" @default.
• W2034184579 hasPublicationYear "2010" @default.
• W2034184579 type Work @default.
• W2034184579 sameAs 2034184579 @default.
• W2034184579 citedByCount "22" @default.
• W2034184579 countsByYear W20341845792012 @default.
• W2034184579 countsByYear W20341845792013 @default.
• W2034184579 countsByYear W20341845792014 @default.
• W2034184579 countsByYear W20341845792015 @default.
• W2034184579 countsByYear W20341845792016 @default.
• W2034184579 countsByYear W20341845792017 @default.
• W2034184579 countsByYear W20341845792019 @default.
• W2034184579 countsByYear W20341845792020 @default.
• W2034184579 countsByYear W20341845792021 @default.
• W2034184579 countsByYear W20341845792023 @default.
• W2034184579 crossrefType "journal-article" @default.
• W2034184579 hasAuthorship W2034184579A5008575045 @default.
• W2034184579 hasAuthorship W2034184579A5009076376 @default.
• W2034184579 hasAuthorship W2034184579A5018201691 @default.
• W2034184579 hasAuthorship W2034184579A5045779549 @default.
• W2034184579 hasAuthorship W2034184579A5049119597 @default.
• W2034184579 hasAuthorship W2034184579A5067451569 @default.
• W2034184579 hasAuthorship W2034184579A5077231720 @default.
• W2034184579 hasBestOaLocation W20341845791 @default.
• W2034184579 hasConcept C126322002 @default.
• W2034184579 hasConcept C134018914 @default.
• W2034184579 hasConcept C171056886 @default.
• W2034184579 hasConcept C202751555 @default.
• W2034184579 hasConcept C2776151105 @default.

• next