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• W2034184927 abstract "Preparation of a novel c(RGDyK) targeted SN38 prodrug incorporating an indolequinone structure for bioreductively triggered drug release is described. This design yields a prodrug that targets surface molecules on tumor cells (αvβ3 integrins) and releases drug under bioreductive conditions. There are three moieties in the prodrug design, namely a therapeutic drug SN38, an indolequinone structure serving as a drug releasing trigger, and an αvβ3 integrin targeting peptide c(RGDyK). Preliminary studies showed that SN38 is released in the presence of a bioreductive enzyme (DT-diaphorase)." @default.
• W2034184927 created "2016-06-24" @default.
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• W2034184927 date "2010-03-01" @default.
• W2034184927 modified "2023-09-26" @default.
• W2034184927 title "The Synthesis of a c(RGDyK) Targeted SN38 Prodrug with an Indolequinone Structure for Bioreductive Drug Release" @default.
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• W2034184927 doi "https://doi.org/10.1021/ol1002626" @default.
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