Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034186186> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2034186186 endingPage "1252" @default.
- W2034186186 startingPage "1244" @default.
- W2034186186 abstract "Paclitaxel is a chemotherapeutic agent used for the treatment of metastatic breast cancer. 2,5,7,8-Tetramethyl-2R-(4R, 8R-12-trimethyltridecyl) chroman-6-yloxyacetic acid (α-TEA) is an analog of vitamin E that inhibits primary tumor growth and the incidence of lymphatic and pulmonary metastases in preclinical animal models. Here, the efficacy of sequential treatment with paclitaxel and α-TEA was tested in the BALB/c syngeneic 66cl-4-GFP mammary cancer model. Both agents were formulated into liposomes and delivered by inhalation in an effort to increase anti-tumor efficacy and minimize paclitaxel toxicity. Combination treatment consisting of twelve days of every-other-day treatment with aerosolized paclitaxel (approximately 0.46 μg/mouse/treatment) followed by a daily regimen of aerosolized α-TEA (36 μg/mouse/treatment) significantly decreased primary tumor burden when compared to untreated or liposome control groups and was significantly better than individual treatments ( P < 0.05). Importantly, combination treatment was significantly better at reducing lung and lymph node micrometastatic foci when compared to control and individual treatment groups ( P < 0.05). Immunohistochemical analyses of tumor sections showed combination treatment when compared to liposome control or individual treatments to significantly decrease total number of cells staining positive for the endothelial cell marker CD31 or for the Ki67 marker of cellular proliferation and increase the number of apoptotic (TUNEL positive) tumor cells ( P < 0.001). Studies addressing the toxicity of α-TEA demonstrated that α-TEA formulated in liposomes and delivered by aerosol (72 μg/mouse/day) or gavage (5 mg/mouse/day) for 25 days did not cause blood, liver, or kidney toxicity. In conclusion, sequential inhalation delivery of liposomal-formulated paclitaxel and α-TEA produces significantly better anti-tumor outcomes than single treatments." @default.
- W2034186186 created "2016-06-24" @default.
- W2034186186 creator A5000233609 @default.
- W2034186186 creator A5048696544 @default.
- W2034186186 creator A5062277760 @default.
- W2034186186 creator A5062322263 @default.
- W2034186186 creator A5065193080 @default.
- W2034186186 creator A5065801484 @default.
- W2034186186 creator A5073694517 @default.
- W2034186186 date "2009-10-01" @default.
- W2034186186 modified "2023-10-17" @default.
- W2034186186 title "Aerosol Delivery of Liposomal Formulated Paclitaxel and Vitamin E Analog Reduces Murine Mammary Tumor Burden and Metastases" @default.
- W2034186186 cites W1535472961 @default.
- W2034186186 cites W1569619304 @default.
- W2034186186 cites W1606837855 @default.
- W2034186186 cites W1866952059 @default.
- W2034186186 cites W1919984048 @default.
- W2034186186 cites W1974855616 @default.
- W2034186186 cites W1976238224 @default.
- W2034186186 cites W1979517547 @default.
- W2034186186 cites W1985017687 @default.
- W2034186186 cites W2020157942 @default.
- W2034186186 cites W2033897643 @default.
- W2034186186 cites W2050364495 @default.
- W2034186186 cites W2079794940 @default.
- W2034186186 cites W2080344761 @default.
- W2034186186 cites W2087826750 @default.
- W2034186186 cites W2100014422 @default.
- W2034186186 cites W2107969818 @default.
- W2034186186 cites W2111868506 @default.
- W2034186186 cites W2119751608 @default.
- W2034186186 cites W2144536924 @default.
- W2034186186 cites W4251759901 @default.
- W2034186186 doi "https://doi.org/10.3181/0901-rm-8" @default.
- W2034186186 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19657067" @default.
- W2034186186 hasPublicationYear "2009" @default.
- W2034186186 type Work @default.
- W2034186186 sameAs 2034186186 @default.
- W2034186186 citedByCount "45" @default.
- W2034186186 countsByYear W20341861862012 @default.
- W2034186186 countsByYear W20341861862013 @default.
- W2034186186 countsByYear W20341861862014 @default.
- W2034186186 countsByYear W20341861862015 @default.
- W2034186186 countsByYear W20341861862016 @default.
- W2034186186 countsByYear W20341861862017 @default.
- W2034186186 countsByYear W20341861862019 @default.
- W2034186186 countsByYear W20341861862020 @default.
- W2034186186 countsByYear W20341861862021 @default.
- W2034186186 crossrefType "journal-article" @default.
- W2034186186 hasAuthorship W2034186186A5000233609 @default.
- W2034186186 hasAuthorship W2034186186A5048696544 @default.
- W2034186186 hasAuthorship W2034186186A5062277760 @default.
- W2034186186 hasAuthorship W2034186186A5062322263 @default.
- W2034186186 hasAuthorship W2034186186A5065193080 @default.
- W2034186186 hasAuthorship W2034186186A5065801484 @default.
- W2034186186 hasAuthorship W2034186186A5073694517 @default.
- W2034186186 hasConcept C105702510 @default.
- W2034186186 hasConcept C121608353 @default.
- W2034186186 hasConcept C126322002 @default.
- W2034186186 hasConcept C142724271 @default.
- W2034186186 hasConcept C2776954882 @default.
- W2034186186 hasConcept C2777292972 @default.
- W2034186186 hasConcept C29730261 @default.
- W2034186186 hasConcept C502942594 @default.
- W2034186186 hasConcept C71924100 @default.
- W2034186186 hasConcept C82085835 @default.
- W2034186186 hasConcept C98274493 @default.
- W2034186186 hasConceptScore W2034186186C105702510 @default.
- W2034186186 hasConceptScore W2034186186C121608353 @default.
- W2034186186 hasConceptScore W2034186186C126322002 @default.
- W2034186186 hasConceptScore W2034186186C142724271 @default.
- W2034186186 hasConceptScore W2034186186C2776954882 @default.
- W2034186186 hasConceptScore W2034186186C2777292972 @default.
- W2034186186 hasConceptScore W2034186186C29730261 @default.
- W2034186186 hasConceptScore W2034186186C502942594 @default.
- W2034186186 hasConceptScore W2034186186C71924100 @default.
- W2034186186 hasConceptScore W2034186186C82085835 @default.
- W2034186186 hasConceptScore W2034186186C98274493 @default.
- W2034186186 hasIssue "10" @default.
- W2034186186 hasLocation W20341861861 @default.
- W2034186186 hasLocation W20341861862 @default.
- W2034186186 hasOpenAccess W2034186186 @default.
- W2034186186 hasPrimaryLocation W20341861861 @default.
- W2034186186 hasRelatedWork W2042762939 @default.
- W2034186186 hasRelatedWork W2045698890 @default.
- W2034186186 hasRelatedWork W2132887061 @default.
- W2034186186 hasRelatedWork W2135538021 @default.
- W2034186186 hasRelatedWork W2169427225 @default.
- W2034186186 hasRelatedWork W2669947340 @default.
- W2034186186 hasRelatedWork W3147219444 @default.
- W2034186186 hasRelatedWork W4206276076 @default.
- W2034186186 hasRelatedWork W4280525182 @default.
- W2034186186 hasRelatedWork W4306154361 @default.
- W2034186186 hasVolume "234" @default.
- W2034186186 isParatext "false" @default.
- W2034186186 isRetracted "false" @default.
- W2034186186 magId "2034186186" @default.
- W2034186186 workType "article" @default.