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• W2034187117 abstract "To improve ultrasound contrast agents targeted to the adhesion molecules P-selectin and VCAM-1 for the purpose of molecular imaging of atherosclerotic plaques, perfluorocarbon-filled phospholipid microbubble contrast agents were coupled by a polyethylene glycol–biotin–streptavidin bridge with mAb MVCAM.A(429), a sialyl Lewisx polymer (PAA-sLex), or both (dual). Approximately three hundred thousand antibody molecules were coupled to the surface of each microbubble. Recombinant mouse P-selectin and/or VCAM-1 coated on flow chambers showed saturation of binding at approximately 15 ng/μl, resulting in 800 and 1200 molecules/µm2 for P-selectin and VCAM-1, respectively. Dual substrates coated with equal concentrations of P-selectin and VCAM-1 had site densities between 50 and 60% of single substrates. When microbubbles were perfused through flow chambers at 5 × 106 microbubbles/ml (wall shear stress from 1.5 to 6 dyn/cm2) dual-targeted microbubbles adhered almost twice as efficiently as single-targeted microbubbles at 6 dyn/cm2. The present study suggests that dual-targeted contrast agents may be useful for atherosclerotic plaque detection at physiologically relevant shear stresses." @default.
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• W2034187117 date "2009-12-01" @default.
• W2034187117 modified "2023-10-03" @default.
• W2034187117 title "Dual targeting improves microbubble contrast agent adhesion to VCAM-1 and P-selectin under flow" @default.
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• W2034187117 doi "https://doi.org/10.1016/j.jconrel.2009.08.001" @default.
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