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• W2034188317 abstract "No AccessJournal of UrologyInvestigative Urology1 Jul 2009Suppression of Bladder Oxidative Stress and Inflammation by a Phytotherapeutic Agent in a Rat Model of Partial Bladder Outlet Obstruction Michiko Oka, Tomomi Fukui, Makoto Ueda, Mitsuhiro Tagaya, Tatsuya Oyama, and Mitsushi Tanaka Michiko OkaMichiko Oka More articles by this author , Tomomi FukuiTomomi Fukui More articles by this author , Makoto UedaMakoto Ueda More articles by this author , Mitsuhiro TagayaMitsuhiro Tagaya More articles by this author , Tatsuya OyamaTatsuya Oyama More articles by this author , and Mitsushi TanakaMitsushi Tanaka More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2009.02.104AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Ischemia/reperfusion injury is a major etiological factor in the progression of bladder dysfunction after partial bladder outlet obstruction and it is partly mediated by the generation of free radicals. The phytotherapeutic agent Eviprostat®, a popular treatment for benign prostatic hyperplasia in Japan and Germany, has antioxidant and anti-inflammatory activity. We investigated the effect of Eviprostat on oxidative stress and inflammation in bladder dysfunction in a bladder outlet obstruction rat model. Materials and Methods: Bladder outlet obstruction was surgically induced in male rats by placing a rubber ring around the urethra. Rats with bladder outlet obstruction were administered daily oral Eviprostat or vehicle, while sham operated animals were treated with vehicle. On day 6 after surgery bladder weight, oxidative stress markers and proinflammatory cytokine levels as a measure of bladder inflammation, were determined and histological alterations noted. Functional contractility studies were performed with longitudinal bladder strips. Results: Bladder outlet obstruction led to a significant increase in bladder weight, oxidative stress markers and proinflammatory cytokine levels. Eviprostat significantly suppressed these increases without affecting bladder weight. Histological analysis showed increased detrusor muscle hypertrophy and increased numbers of collagen fibers with accompanying inflammatory infiltration in the bladder of vehicle treated bladder outlet obstruction animals. Eviprostat treatment was associated with suppression of these changes. Decreased responses of obstructed bladder strips to electrical stimulation and KCl were ameliorated by Eviprostat treatment. Conclusions: Eviprostat mediated decrease of the increased oxidative stress and bladder inflammation caused by bladder outlet obstruction may contribute to the protection of bladder function. References 1 : Animal models of bladder outlet obstruction and molecular insights into the basis for the development of bladder dysfunction. 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Clin Chim Acta2003; 334: 87. Google Scholar 19 : Seminal plasma cytokines and chemokines in prostate inflammation: interleukin 8 as a predictive biomarker in chronic prostatitis/chronic pelvic pain syndrome and benign prostatic hyperplasia. Eur Urol2007; 51: 524. Google Scholar 20 : Null mutation in macrophage migration inhibitory factor prevents muscle cell loss and fibrosis in partial bladder outlet obstruction. Am J Physiol Renal Physiol2006; 291: F1343. Google Scholar 21 : Urethra is more sensitive to ischemia than bladder: evidence from an in vitro rat study. J Urol2001; 165: 2086. Link, Google Scholar Research Laboratories, Nippon Shinyaku Co., Ltd., Kyoto, Japan© 2009 by American Urological AssociationFiguresReferencesRelatedDetailsCited byHughes F, Hill H, Wood C, Edmondson A, Dumas A, Foo W, Oelsen J, Rac G and Purves J (2015) The NLRP3 Inflammasome Mediates Inflammation Produced by Bladder Outlet ObstructionJournal of Urology, VOL. 195, NO. 5, (1598-1605), Online publication date: 1-May-2016.Miyazaki N, Yamaguchi O, Nomiya M, Aikawa K and Kimura J (2015) Preventive Effect of Hydrogen Water on the Development of Detrusor Overactivity in a Rat Model of Bladder Outlet ObstructionJournal of Urology, VOL. 195, NO. 3, (780-787), Online publication date: 1-Mar-2016.Lin W, Hsieh C, Yang T, Chen M, Huang L, Lin Y, Chang P, Levin R and Wei Y (2014) Transient Increase in Circulating Myeloid-Derived Suppressor Cells after Partial Bladder Outlet ObstructionJournal of Urology, VOL. 192, NO. 5, (1569-1573), Online publication date: 1-Nov-2014.Griebling T (2013) Re: Influence of Oxidative Stress on Inducing Micturition Dysfunction Following Chronic Infravesical Obstruction and the Protective Role of an Antioxidant Diet—Association of In Vivo and In Vitro Studies in RatsJournal of Urology, VOL. 189, NO. 6, (2207-2208), Online publication date: 1-Jun-2013.Nasrin S, Masuda E, Kugaya H, Ito Y and Yamada S (2012) Improvement by Phytotherapeutic Agent of Detrusor Overactivity, Down-Regulation of Pharmacological Receptors and Urinary Cytokines in Rats with Cyclophosphamide Induced CystitisJournal of Urology, VOL. 189, NO. 3, (1123-1129), Online publication date: 1-Mar-2013. Volume 182Issue 1July 2009Page: 382-390 Advertisement Copyright & Permissions© 2009 by American Urological AssociationKeywordsbenign prostatic hyperplasiaoxidative stressproinflammatory cytokinesEviprostatbladder outlet obstructionAcknowledgmentsDr. G. E. Smyth, Nippon Shinyaku Co., Ltd. provided suggestions about the manuscript.MetricsAuthor Information Michiko Oka More articles by this author Tomomi Fukui More articles by this author Makoto Ueda More articles by this author Mitsuhiro Tagaya More articles by this author Tatsuya Oyama More articles by this author Mitsushi Tanaka More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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