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• W2034188674 abstract "The activity of various methylating, ethylating, and propylating agents in DNA alkylation in vitro and in vivo, in decreasing transforming activity when DNA is treated in vitro and in vivo, in cell killing, and in induction of mutations have been studied in B. subtilis. The extent and the order of activity of these agents in all the above phenomena depended not only on the concentration, and on the nature of the alkylating group, but also on the anionic residue, and this order was different for DNA alkylation in vitro, for cell killing and for induction of mutations; thus, both parts of the alkylating molecule determine the reactivity towards DNA, and may be toxic to the cell also by reactions other than with DNA. While, as expected, the extent of DNA alkylation in vitro was much greater than in vivo, unexpectedly the decrease of transforming activity was less in vitro than in vivo; this may be due to an enzyme breaking alkylated DNA in the cell and/or during extraction. This intracellular process may be more lethal than the one resulting from the extent of DNA alkylation itself. At the same molarity, ethylating agents are less active than methylating, in all the above phenomena; at the same mutagenicity, ethylating agents may be less active (ethyl methanesulfonate) or more active (diethyl sulfate) than methylating, in cell killing, depending on anionic residue. In conclusion, the usefulness of an alkylating agent as a mutagen of low lethality depends on intracellular enzymes and on both parts of the alkylating molecule." @default.
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• W2034188674 date "1970-02-01" @default.
• W2034188674 modified "2023-09-27" @default.
• W2034188674 title "Comparative studies on alkylation of bacterial DNA in vivo and in vitro" @default.
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• W2034188674 doi "https://doi.org/10.1016/0027-5107(70)90052-7" @default.
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