Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034189920> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2034189920 endingPage "283" @default.
- W2034189920 startingPage "277" @default.
- W2034189920 abstract "The effects of pretreatment growth conditions on the sensitivity of tumor cells to various cytotoxic agents were investigated using murine Ehrlich ascites tumor cells grown in two different environments. The tumor cells adapted to grow in the peritoneal cavity of mice were found to be more sensitive to ionizing radiation, oxygen toxicity, doxorubicin, and bleomycin than tumor cells adapted to grow in vitro. However, there was no difference in their sensitivity to 5-fluorouracil. One obvious difference between these two growth environments is oxygen tension; it is between 2.6 and 5.2% (20-40 mmHg) for the peritoneal cavity and 21% (159 mmHg) for the regular tissue culture. To investigate the role of oxygen tension, tumor cells from the peritoneal cavity were grown in tissue culture having either 21% O2 or 4% O2 in the gas phase. Within 4 d, tumor cells that were exposed to 21% O2, but not to 4% O2, in vitro gradually became as resistant to cytotoxic agents as the tumor cells continuously cultured in vitro under 21% O2. It appears that the adaptation of tumor cells to different environments having different partial pressure of oxygen alters their sensitivity not only to oxygen toxicity but also to other cytotoxic agents that damage or kill cells by generating free radicals." @default.
- W2034189920 created "2016-06-24" @default.
- W2034189920 creator A5025894514 @default.
- W2034189920 creator A5070160159 @default.
- W2034189920 date "2003-08-01" @default.
- W2034189920 modified "2023-09-27" @default.
- W2034189920 title "Pretreatment growth environments alter the sensitivity of tumor cells to cytotoxic agents" @default.
- W2034189920 cites W1489284756 @default.
- W2034189920 cites W1768247331 @default.
- W2034189920 cites W1775749144 @default.
- W2034189920 cites W1942812643 @default.
- W2034189920 cites W1971563181 @default.
- W2034189920 cites W1975129370 @default.
- W2034189920 cites W1977229794 @default.
- W2034189920 cites W1978495632 @default.
- W2034189920 cites W1989812133 @default.
- W2034189920 cites W2007064404 @default.
- W2034189920 cites W2009382104 @default.
- W2034189920 cites W2009772673 @default.
- W2034189920 cites W2016445729 @default.
- W2034189920 cites W2039323901 @default.
- W2034189920 cites W2049775789 @default.
- W2034189920 cites W2060338237 @default.
- W2034189920 cites W2082575834 @default.
- W2034189920 cites W2097511505 @default.
- W2034189920 cites W2155826306 @default.
- W2034189920 cites W2166938689 @default.
- W2034189920 doi "https://doi.org/10.1016/s0891-5849(03)00276-4" @default.
- W2034189920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12885589" @default.
- W2034189920 hasPublicationYear "2003" @default.
- W2034189920 type Work @default.
- W2034189920 sameAs 2034189920 @default.
- W2034189920 citedByCount "5" @default.
- W2034189920 crossrefType "journal-article" @default.
- W2034189920 hasAuthorship W2034189920A5025894514 @default.
- W2034189920 hasAuthorship W2034189920A5070160159 @default.
- W2034189920 hasConcept C105702510 @default.
- W2034189920 hasConcept C109316439 @default.
- W2034189920 hasConcept C154317977 @default.
- W2034189920 hasConcept C178790620 @default.
- W2034189920 hasConcept C185592680 @default.
- W2034189920 hasConcept C202751555 @default.
- W2034189920 hasConcept C2776232574 @default.
- W2034189920 hasConcept C2776694085 @default.
- W2034189920 hasConcept C2778536324 @default.
- W2034189920 hasConcept C29730261 @default.
- W2034189920 hasConcept C2993207723 @default.
- W2034189920 hasConcept C502942594 @default.
- W2034189920 hasConcept C540031477 @default.
- W2034189920 hasConcept C54355233 @default.
- W2034189920 hasConcept C55493867 @default.
- W2034189920 hasConcept C86803240 @default.
- W2034189920 hasConceptScore W2034189920C105702510 @default.
- W2034189920 hasConceptScore W2034189920C109316439 @default.
- W2034189920 hasConceptScore W2034189920C154317977 @default.
- W2034189920 hasConceptScore W2034189920C178790620 @default.
- W2034189920 hasConceptScore W2034189920C185592680 @default.
- W2034189920 hasConceptScore W2034189920C202751555 @default.
- W2034189920 hasConceptScore W2034189920C2776232574 @default.
- W2034189920 hasConceptScore W2034189920C2776694085 @default.
- W2034189920 hasConceptScore W2034189920C2778536324 @default.
- W2034189920 hasConceptScore W2034189920C29730261 @default.
- W2034189920 hasConceptScore W2034189920C2993207723 @default.
- W2034189920 hasConceptScore W2034189920C502942594 @default.
- W2034189920 hasConceptScore W2034189920C540031477 @default.
- W2034189920 hasConceptScore W2034189920C54355233 @default.
- W2034189920 hasConceptScore W2034189920C55493867 @default.
- W2034189920 hasConceptScore W2034189920C86803240 @default.
- W2034189920 hasIssue "3" @default.
- W2034189920 hasLocation W20341899201 @default.
- W2034189920 hasLocation W20341899202 @default.
- W2034189920 hasOpenAccess W2034189920 @default.
- W2034189920 hasPrimaryLocation W20341899201 @default.
- W2034189920 hasRelatedWork W1500704576 @default.
- W2034189920 hasRelatedWork W1592022196 @default.
- W2034189920 hasRelatedWork W1990434843 @default.
- W2034189920 hasRelatedWork W2034189920 @default.
- W2034189920 hasRelatedWork W2059893757 @default.
- W2034189920 hasRelatedWork W2323726184 @default.
- W2034189920 hasRelatedWork W2397977721 @default.
- W2034189920 hasRelatedWork W318142626 @default.
- W2034189920 hasRelatedWork W4251777191 @default.
- W2034189920 hasRelatedWork W4319867226 @default.
- W2034189920 hasVolume "35" @default.
- W2034189920 isParatext "false" @default.
- W2034189920 isRetracted "false" @default.
- W2034189920 magId "2034189920" @default.
- W2034189920 workType "article" @default.