FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034190091> ?p ?o ?g. }

• W2034190091 endingPage "230" @default.
• W2034190091 startingPage "223" @default.
• W2034190091 abstract "We have previously demonstrated antileishmanial activity on Leishmania amazonensis of the natural (1–2), synthetic (7) and derivatives of coumarin (−) mammea A/BB (3–6) isolated from the dichloromethane extract of Calophyllum brasiliense leaves. The aim of the present study was to evaluate morphological and ultrastructural alterations in Leishmania amazonensis induced by these compounds. In promastigote forms, all seven compounds produced significant morphological and ultrastructural alterations, as revealed by scanning and transmission electron microscopy. The compound 5,7-dihydroxy-8-(2-methylbutanoyl)-6-(3-methylbutyl)-4-phenyl-chroman-2-one (3), the most active antileishmanial with LD50 of 0.9 μM), induced cell shrinkage and a rounded appearance of the cells. Parasites incubated in the presence of compound (3) showed ultrastructural changes, such as the appearance of mitochondrial swelling with a reduction in the density of the mitochondrial matrix and the presence of vesicles inside the mitochondrion, indicating damage and significant change in this organelle; abnormal chromatin condensation, alterations in the nuclear envelope, intense atypical cytoplasmic vacuolization, and the appearance of autophagic vacuoles were also observed. In addition, the compound (3) may be acting to depolarize the mitochondrial membrane potential of the cells, leading to death of the parasite." @default.
• W2034190091 created "2016-06-24" @default.
• W2034190091 creator A5013117885 @default.
• W2034190091 creator A5015862647 @default.
• W2034190091 creator A5021168609 @default.
• W2034190091 creator A5033944308 @default.
• W2034190091 creator A5052981530 @default.
• W2034190091 creator A5063556772 @default.
• W2034190091 creator A5065479909 @default.
• W2034190091 creator A5076033514 @default.
• W2034190091 creator A5077950384 @default.
• W2034190091 creator A5088383486 @default.
• W2034190091 date "2012-02-01" @default.
• W2034190091 modified "2023-10-16" @default.
• W2034190091 title "Effects of (−) mammea A/BB isolated from Calophyllum brasiliense leaves and derivatives on mitochondrial membrane of Leishmania amazonensis" @default.
• W2034190091 cites W1964308028 @default.
• W2034190091 cites W1968540614 @default.
• W2034190091 cites W1973162807 @default.
• W2034190091 cites W1974828967 @default.
• W2034190091 cites W1982781699 @default.
• W2034190091 cites W1983197880 @default.
• W2034190091 cites W1983730812 @default.
• W2034190091 cites W1991898467 @default.
• W2034190091 cites W1992273384 @default.
• W2034190091 cites W1993841012 @default.
• W2034190091 cites W2000327875 @default.
• W2034190091 cites W2002082176 @default.
• W2034190091 cites W2003102783 @default.
• W2034190091 cites W2011871056 @default.
• W2034190091 cites W2013831908 @default.
• W2034190091 cites W2014255331 @default.
• W2034190091 cites W2017102999 @default.
• W2034190091 cites W2018123954 @default.
• W2034190091 cites W2035609779 @default.
• W2034190091 cites W2036956210 @default.
• W2034190091 cites W2043088098 @default.
• W2034190091 cites W2043125563 @default.
• W2034190091 cites W2043487257 @default.
• W2034190091 cites W2050243833 @default.
• W2034190091 cites W2066606578 @default.
• W2034190091 cites W2066954635 @default.
• W2034190091 cites W2067120561 @default.
• W2034190091 cites W2075648201 @default.
• W2034190091 cites W2077273077 @default.
• W2034190091 cites W2078646408 @default.
• W2034190091 cites W2079869127 @default.
• W2034190091 cites W2084889403 @default.
• W2034190091 cites W2100684082 @default.
• W2034190091 cites W2105105987 @default.
• W2034190091 cites W2136662212 @default.
• W2034190091 cites W2139455549 @default.
• W2034190091 cites W2143877736 @default.
• W2034190091 cites W2145701935 @default.
• W2034190091 cites W2169519459 @default.
• W2034190091 cites W2171043246 @default.
• W2034190091 doi "https://doi.org/10.1016/j.phymed.2011.10.008" @default.
• W2034190091 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22285848" @default.
• W2034190091 hasPublicationYear "2012" @default.
• W2034190091 type Work @default.
• W2034190091 sameAs 2034190091 @default.
• W2034190091 citedByCount "37" @default.
• W2034190091 countsByYear W20341900912013 @default.
• W2034190091 countsByYear W20341900912014 @default.
• W2034190091 countsByYear W20341900912015 @default.
• W2034190091 countsByYear W20341900912016 @default.
• W2034190091 countsByYear W20341900912017 @default.
• W2034190091 countsByYear W20341900912018 @default.
• W2034190091 countsByYear W20341900912019 @default.
• W2034190091 countsByYear W20341900912020 @default.
• W2034190091 countsByYear W20341900912021 @default.
• W2034190091 countsByYear W20341900912022 @default.
• W2034190091 countsByYear W20341900912023 @default.
• W2034190091 crossrefType "journal-article" @default.
• W2034190091 hasAuthorship W2034190091A5013117885 @default.
• W2034190091 hasAuthorship W2034190091A5015862647 @default.
• W2034190091 hasAuthorship W2034190091A5021168609 @default.
• W2034190091 hasAuthorship W2034190091A5033944308 @default.
• W2034190091 hasAuthorship W2034190091A5052981530 @default.
• W2034190091 hasAuthorship W2034190091A5063556772 @default.
• W2034190091 hasAuthorship W2034190091A5065479909 @default.
• W2034190091 hasAuthorship W2034190091A5076033514 @default.
• W2034190091 hasAuthorship W2034190091A5077950384 @default.
• W2034190091 hasAuthorship W2034190091A5088383486 @default.
• W2034190091 hasConcept C102568950 @default.
• W2034190091 hasConcept C136764020 @default.
• W2034190091 hasConcept C168240541 @default.
• W2034190091 hasConcept C185592680 @default.
• W2034190091 hasConcept C190062978 @default.
• W2034190091 hasConcept C2781092759 @default.
• W2034190091 hasConcept C2781371782 @default.
• W2034190091 hasConcept C28859421 @default.
• W2034190091 hasConcept C41008148 @default.
• W2034190091 hasConcept C55493867 @default.
• W2034190091 hasConcept C59822182 @default.
• W2034190091 hasConcept C71928629 @default.
• W2034190091 hasConcept C86803240 @default.
• W2034190091 hasConcept C87555872 @default.
• W2034190091 hasConcept C95444343 @default.

• next