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• W2034190215 abstract "Abstract In the first experiment, 15, 17, 21, 36, 90, and 275-day-old rats were injected with either physiological saline, 0.5, 1.0, 4.0, 8.0, or 16.0 mg/kg of l-amphetamine. In Experiment 2, rats of these ages were injected with saline or comparable doses of d-amphetamine. Starting immediately after the injection, photo-cell crossings and wall climbing were recorded during 15-min intervals for a total of 4 hours. In general, photo-cell crossings in 15-day-old rats were increased more by low doses than higher doses. In 17 and 21-day-old rats, the peak in the dose response curve gradually shifted toward higher doses, until, at 36 days of age, low doses produced no significant change in photo-crossings and the highest doses produced the maximum increase. In the two oldest ages, the dose-response curves for photo-crossings were the typical inverted U function. In adults, d-amphetamine had a more potent action on photo-cell crossings than l-amphetamine. However, in other ages, l-amphetamine appeared to be slightly more potent than d-amphetamine or there were no potency differences between the two isomers. Low doses of both d- and l-amphetamine increased wall climbing in the three youngest ages but higher doses were without effect. In 36-day-old rats, wall climbing was slightly increased by 4.0 mg/kg of d-amphetamine but no dose of either isomer altered wall climbing in adults. Since amphetamine appears to produce behavioral changes by acting on catecholamines, the age-dependent behavioral effects of amphetamine may be due to maturation of central nervous system catecholaminergic neurons. However, involvement of other neurotransmitter systems can not be excluded. In Experiment 3, parahydroxy-amphetamine (1.0, 4.0, and 16.0 mg/kg) did not significantly alter photo-cell crossings or wall climbing in 15, 17, 21, 36, or 90-day-old rats. Because parahydroxy-amphetamine has only peripheral effects, it appears likely that central actions are responsible for the age-dependent behavioral effects of l- and d-amphetamine." @default.
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• W2034190215 date "1980-08-01" @default.
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• W2034190215 title "The effects of l-, d-, and parahydroxy-amphetamine on locomotor activity and wall climbing in rats of different ages" @default.
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• W2034190215 doi "https://doi.org/10.1016/0091-3057(80)90066-0" @default.
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