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• W2034190778 abstract "The effects of intravenous therapy with propranolol (0.15 mg/kg of body weight) on changes in hemodynamics and the sum of precordial elevations of the S-T segment (∑ST) were studied 8.5 hours after the onset of pain in 14 patients with acute anterior transmural myocardial infarction and without complication. Therapy with propranolol (7.5 to 15 mg) produced a significant and sustained decrease from control in ∑ST, amounting to 46 percent (from 41 to 22 mm; P < 0.001) by 30 minutes and 39 percent by four hours. By 30 minutes, simultaneous decreases occurred in the heart rate (78 to 62 beats per minute, or 21 percent; P < 0.001), mean arterial pressure (112 to 98 mm Hg, or 13 percent; P < 0.05), and cardiac index (2.3 to 1.5 L/min/sq m, or 35 percent; P < 0.001), with the corresponding percentage decreases by four hours being 11 percent, 13 percent, and 9 percent, respectively; however, the pulmonary capillary wedge pressure did not change (15 to 14 mm Hg), and no patient developed clinical signs of heart failure. A significant correlation was found over the four hours between changes in the rate-pressure product and ∑ST (r = 0.985; P < 0.001), suggesting that the sustained decrease in ∑ST is due to the effects of a reduction in the rate-pressure product The fall in cardiac index in these patients suggests the need for caution in administering large doses of propranolol in uncomplicated myocardial infarction. The effects of intravenous therapy with propranolol (0.15 mg/kg of body weight) on changes in hemodynamics and the sum of precordial elevations of the S-T segment (∑ST) were studied 8.5 hours after the onset of pain in 14 patients with acute anterior transmural myocardial infarction and without complication. Therapy with propranolol (7.5 to 15 mg) produced a significant and sustained decrease from control in ∑ST, amounting to 46 percent (from 41 to 22 mm; P < 0.001) by 30 minutes and 39 percent by four hours. By 30 minutes, simultaneous decreases occurred in the heart rate (78 to 62 beats per minute, or 21 percent; P < 0.001), mean arterial pressure (112 to 98 mm Hg, or 13 percent; P < 0.05), and cardiac index (2.3 to 1.5 L/min/sq m, or 35 percent; P < 0.001), with the corresponding percentage decreases by four hours being 11 percent, 13 percent, and 9 percent, respectively; however, the pulmonary capillary wedge pressure did not change (15 to 14 mm Hg), and no patient developed clinical signs of heart failure. A significant correlation was found over the four hours between changes in the rate-pressure product and ∑ST (r = 0.985; P < 0.001), suggesting that the sustained decrease in ∑ST is due to the effects of a reduction in the rate-pressure product The fall in cardiac index in these patients suggests the need for caution in administering large doses of propranolol in uncomplicated myocardial infarction." @default.
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• W2034190778 title "Intravenous Therapy with Propranolol in Acute Myocardial Infarction" @default.
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• W2034190778 doi "https://doi.org/10.1378/chest.74.5.514" @default.
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