Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034190985> ?p ?o ?g. }
- W2034190985 endingPage "807" @default.
- W2034190985 startingPage "797" @default.
- W2034190985 abstract "Activation of spinal cord-projecting neurons of the hypothalamic paraventricular nucleus (PVN) has been implicated in a host of sympathetic nervous system functions. Here, we report two distinct activity patterns among electrophysiologically identified PVN spinal neurons that may contribute to the varied functional responses elicited by PVN activation. Extracellular single-unit recording was performed in anesthetized rats, and PVN neurons were antidromically identified by electrical stimulation of the spinal cord (T1-3 or T10-12). Axonal conduction velocity was determined for each identified neuron and revealed two distinct groups of cells, designated Group I (n=19) and Group II (n=34). Conduction velocity was significantly (P<0.01) different between Group I (3.67+/-0.29 m/s) and Group II (0.45+/-0.01 m/s) cells and indicates that axons of Group I cells are larger and/or more heavily myelinated than those of Group II, which appear to be unmyelinated. The majority of Group I (15/19: 79%) and Group II (23/34: 68%) cells discharged spontaneously. Basal firing rates were significantly different between groups (Group I: 2.7+/-0.85 versus Group II: 1.8+/-0.64 spikes s(-1); P<0.05). Spike-triggered averaging of renal sympathetic nerve activity revealed sympathetic-related discharge among a majority of Group I (11/15:73%) and Group II (17/23: 74%) neurons. In addition, seven of 11 Group I cells showed cardiac-related discharge. Pulse-rhythmic discharge was not detectable in any Group II cells tested (n=17). Among 11 Group I cells tested for barosensitivity, discharge in eight (73%) was graded by changes in mean arterial pressure. None of the 16 Group II cells tested for arterial pressure sensitivity responded.We conclude that the PVN spinal pathway is comprised of at least two functionally distinct cell types. The response profile and activity patterns of Group I cells suggest involvement in regulating vasomotor components of sympathetic outflow. By comparison, the activity of Groups II cells suggests a possible role in non-vasomotor sympathetic control." @default.
- W2034190985 created "2016-06-24" @default.
- W2034190985 creator A5043448583 @default.
- W2034190985 creator A5058527875 @default.
- W2034190985 date "2003-05-01" @default.
- W2034190985 modified "2023-10-10" @default.
- W2034190985 title "Identification and characterization of two functionally distinct groups of spinal cord-projecting paraventricular nucleus neurons with sympathetic-related activity" @default.
- W2034190985 cites W1540247375 @default.
- W2034190985 cites W1985267584 @default.
- W2034190985 cites W1990273460 @default.
- W2034190985 cites W1994067213 @default.
- W2034190985 cites W1999230592 @default.
- W2034190985 cites W2018172047 @default.
- W2034190985 cites W2020739776 @default.
- W2034190985 cites W2032641816 @default.
- W2034190985 cites W2035336671 @default.
- W2034190985 cites W2037051306 @default.
- W2034190985 cites W2038167358 @default.
- W2034190985 cites W2041986134 @default.
- W2034190985 cites W2046887050 @default.
- W2034190985 cites W2048060329 @default.
- W2034190985 cites W2051003302 @default.
- W2034190985 cites W2052564270 @default.
- W2034190985 cites W2053936471 @default.
- W2034190985 cites W2061945299 @default.
- W2034190985 cites W2073552026 @default.
- W2034190985 cites W2078430521 @default.
- W2034190985 cites W2086209350 @default.
- W2034190985 cites W2096073712 @default.
- W2034190985 cites W2108349721 @default.
- W2034190985 cites W2121906807 @default.
- W2034190985 cites W2129340317 @default.
- W2034190985 cites W2132307929 @default.
- W2034190985 cites W2137033025 @default.
- W2034190985 cites W2158772868 @default.
- W2034190985 cites W2227539148 @default.
- W2034190985 cites W2297920745 @default.
- W2034190985 doi "https://doi.org/10.1016/s0306-4522(03)00033-2" @default.
- W2034190985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12710987" @default.
- W2034190985 hasPublicationYear "2003" @default.
- W2034190985 type Work @default.
- W2034190985 sameAs 2034190985 @default.
- W2034190985 citedByCount "57" @default.
- W2034190985 countsByYear W20341909852012 @default.
- W2034190985 countsByYear W20341909852013 @default.
- W2034190985 countsByYear W20341909852014 @default.
- W2034190985 countsByYear W20341909852015 @default.
- W2034190985 countsByYear W20341909852016 @default.
- W2034190985 countsByYear W20341909852017 @default.
- W2034190985 countsByYear W20341909852018 @default.
- W2034190985 countsByYear W20341909852019 @default.
- W2034190985 countsByYear W20341909852020 @default.
- W2034190985 countsByYear W20341909852021 @default.
- W2034190985 countsByYear W20341909852023 @default.
- W2034190985 crossrefType "journal-article" @default.
- W2034190985 hasAuthorship W2034190985A5043448583 @default.
- W2034190985 hasAuthorship W2034190985A5058527875 @default.
- W2034190985 hasConcept C105702510 @default.
- W2034190985 hasConcept C126322002 @default.
- W2034190985 hasConcept C134018914 @default.
- W2034190985 hasConcept C169760540 @default.
- W2034190985 hasConcept C179253579 @default.
- W2034190985 hasConcept C185263204 @default.
- W2034190985 hasConcept C185592680 @default.
- W2034190985 hasConcept C24998067 @default.
- W2034190985 hasConcept C2776533406 @default.
- W2034190985 hasConcept C2778794669 @default.
- W2034190985 hasConcept C2780723820 @default.
- W2034190985 hasConcept C2780775167 @default.
- W2034190985 hasConcept C529278444 @default.
- W2034190985 hasConcept C71924100 @default.
- W2034190985 hasConcept C84393581 @default.
- W2034190985 hasConcept C86803240 @default.
- W2034190985 hasConceptScore W2034190985C105702510 @default.
- W2034190985 hasConceptScore W2034190985C126322002 @default.
- W2034190985 hasConceptScore W2034190985C134018914 @default.
- W2034190985 hasConceptScore W2034190985C169760540 @default.
- W2034190985 hasConceptScore W2034190985C179253579 @default.
- W2034190985 hasConceptScore W2034190985C185263204 @default.
- W2034190985 hasConceptScore W2034190985C185592680 @default.
- W2034190985 hasConceptScore W2034190985C24998067 @default.
- W2034190985 hasConceptScore W2034190985C2776533406 @default.
- W2034190985 hasConceptScore W2034190985C2778794669 @default.
- W2034190985 hasConceptScore W2034190985C2780723820 @default.
- W2034190985 hasConceptScore W2034190985C2780775167 @default.
- W2034190985 hasConceptScore W2034190985C529278444 @default.
- W2034190985 hasConceptScore W2034190985C71924100 @default.
- W2034190985 hasConceptScore W2034190985C84393581 @default.
- W2034190985 hasConceptScore W2034190985C86803240 @default.
- W2034190985 hasIssue "3" @default.
- W2034190985 hasLocation W20341909851 @default.
- W2034190985 hasLocation W20341909852 @default.
- W2034190985 hasOpenAccess W2034190985 @default.
- W2034190985 hasPrimaryLocation W20341909851 @default.
- W2034190985 hasRelatedWork W1968401882 @default.
- W2034190985 hasRelatedWork W1984619393 @default.
- W2034190985 hasRelatedWork W2034768996 @default.
- W2034190985 hasRelatedWork W2042786471 @default.