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- W203419170 abstract "Attempts are being made to identify the native conformation of a protein by minimizing its (empirical) conformational energy. To circumvent the multiple-minima problem, a polypeptide chain is built up from low-energy conformations of shorter segments. After the minimum-energy conformations have been located, their energies are recalculated with the inclusion of a term for the free energy of solvation; this leads to a re-ordering of the energies of each segment, and the low-energy conformations of the re-ordered sets are used to build up larger segments. The methodology has been applied successfully to various model peptide systems, and is used here to begin the computation of the 156-residue protein, human leukocyte interferon. In spite of the large number of low-energy conformations of small segments that must be stored, and the large amount of time required to minimize the energy of longer and longer segments, the computations are feasible because they can be parallelized. The procedure is readily adapted for parallel processing by several array processors operating in a quasi-independent manner, and such computations are being carried out on a system of “loosely coupled array processors”. Preliminary results are reported for three segments of interferon containing 29, 9, and 8 residues, respectively. The low-energy conformations of the 29-residue segment from position 122 to 150 all take the form of two roughly anti-parallel α-helices joined by a hinge containing Cys139. The 9-residue segment from position 60 to 68 adopts low-energy conformations that are almost totally α-helical, suggesting strongly that it forms part of an α-helix in the native protein. The low-energy conformations of the 8-residue fragment from position 100 to 107 are all irregular with an apparent chain reversal, suggesting that this part of the molecule links two ?-helices in the native protein. The results show that parallel processing constitutes a powerful approach to the massive computational effort involved in predicting the native conformations of globular proteins from thermodynamic principles." @default.
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- W203419170 date "1986-01-01" @default.
- W203419170 modified "2023-10-15" @default.
- W203419170 title "Parallelism in Conformational Energy Calculations on Proteins" @default.
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- W203419170 cites W1972254209 @default.
- W203419170 cites W1974279943 @default.
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- W203419170 cites W1986964506 @default.
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- W203419170 cites W1999612183 @default.
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- W203419170 doi "https://doi.org/10.1007/978-3-642-51060-1_8" @default.
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