FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034192004> ?p ?o ?g. }

• W2034192004 endingPage "e86800" @default.
• W2034192004 startingPage "e86800" @default.
• W2034192004 abstract "MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression and have multiple effects in various tissues including adipose inflammation, a condition characterized by increased local release of the pro-lipolytic cytokine tumor necrosis factor-alpha (TNF-α). Whether miRNAs regulate adipocyte lipolysis is unknown. We set out to determine whether miRNAs affect adipocyte lipolysis in human fat cells. To this end, eleven miRNAs known to be present in human adipose tissue were over-expressed in human in vitro differentiated adipocytes followed by assessments of TNF-α and glycerol levels in conditioned media after 48 h. Three miRNAs (miR-145, -26a and let-7d) modulated both parameters in parallel. However, while miR-26a and let-7d decreased, miR-145 increased both glycerol release and TNF-α secretion. Further studies were focused therefore on miR-145 since this was the only stimulator of lipolysis and TNF-α secretion. Time-course analysis demonstrated that miR-145 over-expression up-regulated TNF-α expression/secretion followed by increased glycerol release. Increase in TNF-α production by miR-145 was mediated via activation of p65, a member of the NF-κB complex. In addition, miR-145 down-regulated the expression of the protease ADAM17, resulting in an increased fraction of membrane bound TNF-α, which is the more biologically active form of TNF-α. MiR-145 overexpression also increased the phosphorylation of activating serine residues in hormone sensitive lipase and decreased the mRNA expression of phosphodiesterase 3B, effects which are also observed upon TNF-α treatment in human adipocytes. We conclude that miR-145 regulates adipocyte lipolysis via multiple mechanisms involving increased production and processing of TNF-α in fat cells." @default.
• W2034192004 created "2016-06-24" @default.
• W2034192004 creator A5038112028 @default.
• W2034192004 creator A5039358596 @default.
• W2034192004 creator A5043986060 @default.
• W2034192004 creator A5044340612 @default.
• W2034192004 creator A5061540235 @default.
• W2034192004 creator A5065760843 @default.
• W2034192004 creator A5069393217 @default.
• W2034192004 creator A5073281192 @default.
• W2034192004 date "2014-01-24" @default.
• W2034192004 modified "2023-10-18" @default.
• W2034192004 title "MicroRNAs Regulate Human Adipocyte Lipolysis: Effects of miR-145 Are Linked to TNF-α" @default.
• W2034192004 cites W144423133 @default.
• W2034192004 cites W1501675811 @default.
• W2034192004 cites W1573349870 @default.
• W2034192004 cites W1641228030 @default.
• W2034192004 cites W1998463022 @default.
• W2034192004 cites W1999077632 @default.
• W2034192004 cites W2007194743 @default.
• W2034192004 cites W2030170677 @default.
• W2034192004 cites W2031967041 @default.
• W2034192004 cites W2035922648 @default.
• W2034192004 cites W2041335773 @default.
• W2034192004 cites W2055627344 @default.
• W2034192004 cites W2070866093 @default.
• W2034192004 cites W2076641778 @default.
• W2034192004 cites W2077138237 @default.
• W2034192004 cites W2085486418 @default.
• W2034192004 cites W2088543680 @default.
• W2034192004 cites W2116726599 @default.
• W2034192004 cites W2116857073 @default.
• W2034192004 cites W2119445810 @default.
• W2034192004 cites W2125937596 @default.
• W2034192004 cites W2126618865 @default.
• W2034192004 cites W2152988512 @default.
• W2034192004 cites W2153178530 @default.
• W2034192004 cites W2153419357 @default.
• W2034192004 cites W2161012482 @default.
• W2034192004 cites W2164331614 @default.
• W2034192004 cites W2171260596 @default.
• W2034192004 cites W2342149286 @default.
• W2034192004 doi "https://doi.org/10.1371/journal.pone.0086800" @default.
• W2034192004 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3901697" @default.
• W2034192004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24475180" @default.
• W2034192004 hasPublicationYear "2014" @default.
• W2034192004 type Work @default.
• W2034192004 sameAs 2034192004 @default.
• W2034192004 citedByCount "81" @default.
• W2034192004 countsByYear W20341920042014 @default.
• W2034192004 countsByYear W20341920042015 @default.
• W2034192004 countsByYear W20341920042016 @default.
• W2034192004 countsByYear W20341920042017 @default.
• W2034192004 countsByYear W20341920042018 @default.
• W2034192004 countsByYear W20341920042019 @default.
• W2034192004 countsByYear W20341920042020 @default.
• W2034192004 countsByYear W20341920042021 @default.
• W2034192004 countsByYear W20341920042022 @default.
• W2034192004 countsByYear W20341920042023 @default.
• W2034192004 crossrefType "journal-article" @default.
• W2034192004 hasAuthorship W2034192004A5038112028 @default.
• W2034192004 hasAuthorship W2034192004A5039358596 @default.
• W2034192004 hasAuthorship W2034192004A5043986060 @default.
• W2034192004 hasAuthorship W2034192004A5044340612 @default.
• W2034192004 hasAuthorship W2034192004A5061540235 @default.
• W2034192004 hasAuthorship W2034192004A5065760843 @default.
• W2034192004 hasAuthorship W2034192004A5069393217 @default.
• W2034192004 hasAuthorship W2034192004A5073281192 @default.
• W2034192004 hasBestOaLocation W20341920041 @default.
• W2034192004 hasConcept C104317684 @default.
• W2034192004 hasConcept C126322002 @default.
• W2034192004 hasConcept C134018914 @default.
• W2034192004 hasConcept C140985366 @default.
• W2034192004 hasConcept C145059251 @default.
• W2034192004 hasConcept C171089720 @default.
• W2034192004 hasConcept C17991360 @default.
• W2034192004 hasConcept C185592680 @default.
• W2034192004 hasConcept C2776175234 @default.
• W2034192004 hasConcept C2778690821 @default.
• W2034192004 hasConcept C55493867 @default.
• W2034192004 hasConcept C71924100 @default.
• W2034192004 hasConcept C86803240 @default.
• W2034192004 hasConcept C95444343 @default.
• W2034192004 hasConceptScore W2034192004C104317684 @default.
• W2034192004 hasConceptScore W2034192004C126322002 @default.
• W2034192004 hasConceptScore W2034192004C134018914 @default.
• W2034192004 hasConceptScore W2034192004C140985366 @default.
• W2034192004 hasConceptScore W2034192004C145059251 @default.
• W2034192004 hasConceptScore W2034192004C171089720 @default.
• W2034192004 hasConceptScore W2034192004C17991360 @default.
• W2034192004 hasConceptScore W2034192004C185592680 @default.
• W2034192004 hasConceptScore W2034192004C2776175234 @default.
• W2034192004 hasConceptScore W2034192004C2778690821 @default.
• W2034192004 hasConceptScore W2034192004C55493867 @default.
• W2034192004 hasConceptScore W2034192004C71924100 @default.
• W2034192004 hasConceptScore W2034192004C86803240 @default.
• W2034192004 hasConceptScore W2034192004C95444343 @default.
• W2034192004 hasIssue "1" @default.

• next