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- W2034192945 abstract "ancer is a leading cause of death worldwide (7). As economies develop, and the world population grows and C ages, the global burden of cancer continues to increase. Although there are regional differences in the prevalence and distribution of cancer risk factors, cancer detection practices, and the availability and use of various treatment modalities, improvements in cancer diagnosis and treatment are far reaching. Advances in the detection of and therapeutic interventions for systemic solid neoplasms have improved median survival times. In turn, longer survival has increased the prevalence of “safe harbor” metastases. For those cancers that have a predilection to metastasize to the central nervous system—breast, lung, melanoma, and renal cancers—improvements in the oncologic armamentaria have greatly increased the likelihood of developing brain metastases. For instance, in the United States, the incidence of brain metastases in patients with known solid tumors was just more than 5% in the 1960s. Now the incidence is approximately 20% (4). In addition, improved mortality patterns for less common cancers, and cancers with historically poor survival, will likely be reflected in the prevalence of cerebral metastatic disease." @default.
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- W2034192945 date "2014-01-01" @default.
- W2034192945 modified "2023-09-27" @default.
- W2034192945 title "Cerebral Metastatic Disease: Applying What We Know to Rare Brain Metastases" @default.
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- W2034192945 doi "https://doi.org/10.1016/j.wneu.2013.03.061" @default.
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