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- W2034193917 abstract "Asymmetric fluid flow in the node and Nodal signaling in the left lateral plate mesoderm (LPM) drive left-right patterning of the mammalian body plan. However, the mechanisms linking fluid flow to asymmetric gene expression in the LPM remain unclear. Here we show that the small GTPase Rab23, known for its role in Hedgehog signaling, plays a separate role in Nodal signaling and left-right patterning in the mouse embryo. Rab23 is not required for initial symmetry breaking in the node, but it is required for expression of Nodal and Nodal target genes in the LPM. Microinjection of Nodal protein and transfection of Nodal cDNA in the embryo indicate that Rab23 is required for the production of functional Nodal signals, rather than the response to them. Using gain- and loss-of function approaches, we show that Rab23 plays a similar role in zebrafish, where it is required in the teleost equivalent of the mouse node, Kupffer׳s vesicle. Collectively, these data suggest that Rab23 is an essential component of the mechanism that transmits asymmetric patterning information from the node to the LPM." @default.
- W2034193917 created "2016-06-24" @default.
- W2034193917 creator A5047583172 @default.
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- W2034193917 creator A5050330921 @default.
- W2034193917 creator A5054206754 @default.
- W2034193917 creator A5071770281 @default.
- W2034193917 date "2014-07-01" @default.
- W2034193917 modified "2023-09-23" @default.
- W2034193917 title "Rab23 regulates Nodal signaling in vertebrate left–right patterning independently of the Hedgehog pathway" @default.
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- W2034193917 doi "https://doi.org/10.1016/j.ydbio.2014.04.012" @default.
- W2034193917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24780629" @default.
- W2034193917 hasPublicationYear "2014" @default.
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