FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034194022> ?p ?o ?g. }

• W2034194022 endingPage "384" @default.
• W2034194022 startingPage "372" @default.
• W2034194022 abstract "Our purpose was to characterize changes in bone remodeling associated with localized radiation that models therapeutic cancer treatment in ovary-intact (I) and ovariectomized (OVX) mice and to evaluate the influence of radiation on the pattern of bone mineral remodeling. Young adult, female BALB/c mice, I and OVX, were used (n = 71). All mice were intravenously injected with 15 μCi 45Ca. Thirty days post-45Ca administration, the hind limbs of 17 mice were exposed to a single dose of 16 Gy radiation (R). The time course of 45Ca excretion, serum CTx and osteocalcin markers, and cancellous bone volume fraction (BV/TV) and cortical thickness (Ct.Th) of the distal femur were assayed. Cellular activity and dynamic histomorphometry were performed. Irradiation resulted in rapid increases in fecal 45Ca excretion compared to control groups, indicating increased bone remodeling. CTx increased rapidly after irradiation, followed by an increase in osteocalcin concentration. BV/TV decreased in the I mice following irradiation. Ct.Th increased in the OVX groups following irradiation. I+R mice exhibited diminished osteoblast surface, osteoclast number, and mineral apposition. Our murine model showed the systemic effects (via 45Ca excretion) and local effects (via bone microarchitecture and surface activity) of clinically relevant, therapeutic radiation exposure. The I and OVX murine models have similar 45Ca excretion but different bone microarchitectural responses. The 45Ca assay effectively indicates the onset and rate of systemic bone mineral remodeling, providing real-time assessment of changes in bone histomorphometric parameters. Monitoring bone health via a bone mineral marker may help to identify the appropriate time for clinical intervention to preserve skeletal integrity." @default.
• W2034194022 created "2016-06-24" @default.
• W2034194022 creator A5003964326 @default.
• W2034194022 creator A5005461604 @default.
• W2034194022 creator A5030715622 @default.
• W2034194022 creator A5035501764 @default.
• W2034194022 creator A5040357722 @default.
• W2034194022 creator A5044937761 @default.
• W2034194022 creator A5051041792 @default.
• W2034194022 creator A5056845004 @default.
• W2034194022 creator A5066898323 @default.
• W2034194022 creator A5076244808 @default.
• W2034194022 date "2013-01-12" @default.
• W2034194022 modified "2023-09-30" @default.
• W2034194022 title "The Influence of Therapeutic Radiation on the Patterns of Bone Remodeling in Ovary-Intact and Ovariectomized Mice" @default.
• W2034194022 cites W1966853096 @default.
• W2034194022 cites W1967733733 @default.
• W2034194022 cites W1967976996 @default.
• W2034194022 cites W1981355555 @default.
• W2034194022 cites W1982156095 @default.
• W2034194022 cites W2005480554 @default.
• W2034194022 cites W2007401398 @default.
• W2034194022 cites W2010638468 @default.
• W2034194022 cites W2016857891 @default.
• W2034194022 cites W2021511349 @default.
• W2034194022 cites W2027905492 @default.
• W2034194022 cites W2042479818 @default.
• W2034194022 cites W2043846218 @default.
• W2034194022 cites W2049180403 @default.
• W2034194022 cites W2053857652 @default.
• W2034194022 cites W2060298455 @default.
• W2034194022 cites W2066749771 @default.
• W2034194022 cites W2068523275 @default.
• W2034194022 cites W2074254807 @default.
• W2034194022 cites W2085072070 @default.
• W2034194022 cites W2087378917 @default.
• W2034194022 cites W2091806192 @default.
• W2034194022 cites W2096234941 @default.
• W2034194022 cites W2099611307 @default.
• W2034194022 cites W2100923989 @default.
• W2034194022 cites W2110670561 @default.
• W2034194022 cites W2113697838 @default.
• W2034194022 cites W2142338870 @default.
• W2034194022 cites W2156938611 @default.
• W2034194022 cites W2162254379 @default.
• W2034194022 cites W2324013865 @default.
• W2034194022 doi "https://doi.org/10.1007/s00223-012-9688-0" @default.
• W2034194022 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3595353" @default.
• W2034194022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23314741" @default.
• W2034194022 hasPublicationYear "2013" @default.
• W2034194022 type Work @default.
• W2034194022 sameAs 2034194022 @default.
• W2034194022 citedByCount "10" @default.
• W2034194022 countsByYear W20341940222013 @default.
• W2034194022 countsByYear W20341940222014 @default.
• W2034194022 countsByYear W20341940222016 @default.
• W2034194022 countsByYear W20341940222019 @default.
• W2034194022 countsByYear W20341940222021 @default.
• W2034194022 crossrefType "journal-article" @default.
• W2034194022 hasAuthorship W2034194022A5003964326 @default.
• W2034194022 hasAuthorship W2034194022A5005461604 @default.
• W2034194022 hasAuthorship W2034194022A5030715622 @default.
• W2034194022 hasAuthorship W2034194022A5035501764 @default.
• W2034194022 hasAuthorship W2034194022A5040357722 @default.
• W2034194022 hasAuthorship W2034194022A5044937761 @default.
• W2034194022 hasAuthorship W2034194022A5051041792 @default.
• W2034194022 hasAuthorship W2034194022A5056845004 @default.
• W2034194022 hasAuthorship W2034194022A5066898323 @default.
• W2034194022 hasAuthorship W2034194022A5076244808 @default.
• W2034194022 hasBestOaLocation W20341940222 @default.
• W2034194022 hasConcept C10146269 @default.
• W2034194022 hasConcept C126322002 @default.
• W2034194022 hasConcept C131075544 @default.
• W2034194022 hasConcept C134018914 @default.
• W2034194022 hasConcept C142724271 @default.
• W2034194022 hasConcept C160160445 @default.
• W2034194022 hasConcept C170033053 @default.
• W2034194022 hasConcept C170493617 @default.
• W2034194022 hasConcept C181199279 @default.
• W2034194022 hasConcept C185592680 @default.
• W2034194022 hasConcept C202751555 @default.
• W2034194022 hasConcept C2776033226 @default.
• W2034194022 hasConcept C2776350087 @default.
• W2034194022 hasConcept C2776541429 @default.
• W2034194022 hasConcept C2776886416 @default.
• W2034194022 hasConcept C2777164284 @default.
• W2034194022 hasConcept C2778260815 @default.
• W2034194022 hasConcept C2778324911 @default.
• W2034194022 hasConcept C55493867 @default.
• W2034194022 hasConcept C71924100 @default.
• W2034194022 hasConcept C8264082 @default.
• W2034194022 hasConceptScore W2034194022C10146269 @default.
• W2034194022 hasConceptScore W2034194022C126322002 @default.
• W2034194022 hasConceptScore W2034194022C131075544 @default.
• W2034194022 hasConceptScore W2034194022C134018914 @default.
• W2034194022 hasConceptScore W2034194022C142724271 @default.
• W2034194022 hasConceptScore W2034194022C160160445 @default.
• W2034194022 hasConceptScore W2034194022C170033053 @default.

• next